Thyroid hormone status in patients with severe selenium deficiency.
Thyroid hormone status in patients with severe selenium deficiency.
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DOI：
10.1297/cpe.27.67
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Ida S
中科院分区：
文献类型：
--
作者：
Kawai M;Shoji Y;Onuma S;Etani Y;Ida S
硒(Se)是一种必需的微量元素，以碘甲状腺原氨酸脱碘酶(DIO)等硒蛋白的形式参与多种生物过程。Se缺乏可能通过降低DIO的表达从而影响甲状腺激素的状态，从而阻止T4向T3的转化。然而，这在人类身上还没有很好的记录。在这项研究中，为了阐明硒和甲状腺激素状况之间的关系，我们调查了严重缺硒患者的甲状腺激素水平(<；2微克/分升)。严重的硒缺乏与游离T4水平的升高有关，而与游离T3和促甲状腺激素(TSH)水平的降低和升高无关。补充Se可降低Se缺乏时游离T4水平的升高，但不影响游离T3和TSH水平。综上所述，这些发现表明，当血清硒水平严重低时，游离T4可能是一种有用的硒状态生物标志物。
Selenium (Se) is an essential trace element that is involved in numerous biological processes in the form of a selenoprotein such as iodothyronine deiodinase (DIO). Se deficiency may prevent the conversion of T4 to T3 through reducing DIO expression and thereby affecting thyroid hormone status. However, this has not been well documented in humans. In this study, to clarify the association between Se and thyroid hormone status, we investigated the thyroid hormone levels in patients with severe Se deficiency (< 2 µg/dl). Severe Se deficiency was associated with increases in free T4 levels, but not with decreases and increases in free T3 and thyroid stimulating hormone (TSH) levels, respectively. Increases in free T4 levels during Se deficiency were reduced with Se supplementation; however, neither free T3 nor TSH levels were affected. Taken together, these findings indicate that free T4 may be a useful biomarker for Se status when serum Se levels are severely low.