ALTERED HIPPOCAMPAL NETWORK EXCITABILITY IN THE HYPERNORADRENERGIC MUTANT MOUSE TOTTERING
ALTERED HIPPOCAMPAL NETWORK EXCITABILITY IN THE HYPERNORADRENERGIC MUTANT MOUSE TOTTERING
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DOI：
10.1016/0006-8993(90)90695-8
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发表时间：
1990-08-06
期刊：
影响因子：
2.9
通讯作者：
RUTECKI, PA
中科院分区：
文献类型：
--
作者：
NOEBELS, JL;RUTECKI, PA
体外通过惊厥激活的同步神经元放电揭示了tg/tg突变小鼠海马网络兴奋性的一种潜在的、与基因相关的改变。暴露于升高的细胞外钾离子或4-氨基吡啶（但不暴露于印防己毒素），显示突变CA 3锥体细胞区域的网络放电持续时间异常延长。在这两种表型中，去甲肾上腺素和选择性β-去甲肾上腺素能受体激动剂异丙肾上腺素可逆地加速放电频率。这些发现确定了一个内在的改变，在一个孤立的神经元网络的兴奋性遗传性全身性棘波癫痫模型，并进一步牵连去甲肾上腺素能机制的海马同步化和癫痫发生的时间调制。
A latent, gene-linked alteration of hippocampal network excitability in tg/tg mutant mice was unmasked invitro by convulsant-activated synchronous neruonal discharges. Exposure to elevated extracellular potassium ions or 4-aminopyridine, but not picrotoxin, revealed an abnormally prolonged network discharge duration in the mutant CA3 pyramidal cell region. In both phenotypes, noradrenaline, and a selective .beta.-noradrenergic receptor agonist, isoproterenol, reversibly accelerated the frequency of the discharges. These findings identify an intrinsic alteration in the excitability of an isolated neuronal network in a model of inherited generalized spike-wave epilepsy, and further implicate noradrenergic mechanisms in the temporal modulation of hippocampal synchronization and epileptogenesis.