Synchronization of electrically induced calcium firings in self-assembled cardiac cells
Synchronization of electrically induced calcium firings in self-assembled cardiac cells
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DOI：
10.1016/j.bpc.2005.01.008
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发表时间：
2005-06-01
影响因子：
3.8
通讯作者：
Hara, M
中科院分区：
文献类型：
--
作者：
Aihara, R;Hara, M
我们研究了细胞群体对外界刺激的适应性变化。二维均匀分布的心肌细胞受到周期性电刺激，同时观察细胞内钙浓度（[Ca 2 +]（i））的变化。在无刺激的情况下，单层的偶联细胞形成多个细胞的群体，以相似的相位振荡，而分离的细胞显示不规则的周期性。在这两个系统中，[Ca 2 +] i振荡都受到周期性刺激的调制，并且随着刺激强度的增加，[Ca 2 +] i振荡之间的同步程度增加。在一群耦合的细胞中，细胞就像一个单一的鲁棒振荡器。这些结果使用统计计算进行评估，比较分离的细胞的响应方式。(c)2005 Elsevier B.V.保留所有权利。
We study the adaptive changes of a population of cells responding to external stimulus. Two-dimensionally distributed cardiac cells were homogeneously subjected to periodic electrical stimulus and intracellular calcium concentration ([Ca2+](i)) changes were simultaneously observed. In the absence of stimulation, coupled cells in monolayer formed groups of several cells oscillating in similar phase, while isolated cells showed irregular periodicity. In both systems, [Ca2+] i oscillations were modulated by periodic stimulation, and ascending degrees of synchronization among [Ca2+](i) oscillations were shown as stimulation intensity increased. In a population of coupled cells, the cells act like a single robust oscillator. These results are evaluated using statistical calculations, comparing the response manner of isolated cells. (c) 2005 Elsevier B.V. All rights reserved.