Studies of Australian ascidians .5. Virenamides A-C, new cytotoxic linear peptides from the colonial didemnid ascidian Diplosoma virens
Studies of Australian ascidians .5. Virenamides A-C, new cytotoxic linear peptides from the colonial didemnid ascidian Diplosoma virens
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DOI：
10.1021/jo951379o
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发表时间：
1996-06-14
影响因子：
3.6
通讯作者：
Coll, JC
中科院分区：
文献类型：
--
作者：
Carroll, AR;Feng, YJ;Coll, JC
从澳大利亚大堡礁海鞘Didemnid ascidian Diplosoma virens的提取物中分离出三个新的线状细胞毒三肽，即病毒酰胺A-C。通过1D和2D NMR数据推断出它们的结构，并采用Marfey方法对肽水解和1-氟-2,4-二硝基苯-5-基- l-丙氨酸酰胺衍生化后的组成氨基酸进行高效液相色谱分析。
Three new linear cytotoxic tripeptides, virenamides A-C have been isolated from extracts of the Didemnid ascidian Diplosoma virens collected on the Great Barrier Reef, Australia. Their structures were deduced from 1D and 2D NMR spectral data and confirmed by HPLC analysis of the constituent amino acids after hydrolysis of the peptides and derivatization with 1-fluoro-2,4-dinitrophen-5-yl-L-alanine amide using Marfey's procedure.