Assignment of the squamous cell carcinoma antigen locus (SCC) to 18q21 by in situ hybridization.
Assignment of the squamous cell carcinoma antigen locus (SCC) to 18q21 by in situ hybridization.
复制标题
通过原位杂交将鳞状细胞癌抗原位点 (SCC) 分配给 18q21。
DOI：
10.1006/geno.1995.1290
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发表时间：
1995
期刊：
影响因子：
4.4
通讯作者：
H. Kato
中科院分区：
文献类型：
--
作者：
A. Kuwano;I. Kondo;F. Kishi;Y. Suminami;H. Kato
鳞状细胞癌（SCC）抗原是一种肿瘤相关蛋白。SCC抗原的表达与正常和恶性鳞状细胞的分化程度密切相关，反映了肿瘤的浸润性生长。鳞状细胞癌细胞比正常鳞状细胞释放更多的SCC抗原。最近，一个人SCC抗原cDNA被分离，氨基酸同源性搜索显示与丝氨酸蛋白酶抑制剂（serpins）家族，包括鸡基因Y蛋白（45%）、纤溶酶原激活物抑制剂-2（PLAH 2）（43%）、卵清蛋白（42%）和抗凝血酶III（39%）的高度同源性。这些结果表明，SCC抗原是一种新的抑制剂，它被假定作为一种调节剂的宿主免疫反应，对肿瘤细胞。在这里，我们定位SCC抗原基因的荧光原位杂交。参考文献6篇，1图
Squamous cell carcinoma (SCC) antigen is a tumor-associated protein. The expression of SCC antigen is closely related to cellular differentiation in both normal and malignant squamous cells, reflecting the infiltrative growth of tumor. More SCC antigen is released from squamous cell carcinoma cells than from normal squamous cells. Recently, a human SCC antigen cDNA was isolated and the amino acid homology search showed high homology with the serine protease inhibitor (serpins) family, including chicken gene Y protein (45%), plasminogen activator inhibitor-2 (PLAH2) (43%), ovalbumin (42%), and antithrombin III (39%). These results indicate that SCC antigen is a novel inhibitor, and it was postulated to act as a modulator of the host immune response against tumor cells. Here, we localized the SCC antigen gene by fluorescence in situ hybridization. 6 refs., 1 fig.