Self-organization of a chiral D-EAK16 designer peptide into a 3D nanofiber scaffold
Self-organization of a chiral D-EAK16 designer peptide into a 3D nanofiber scaffold
复制标题
DOI：
10.1002/mabi.200800003
复制
发表时间：
2008-08-11
影响因子：
4.6
通讯作者：
Zhang, Shuguang
中科院分区：
文献类型：
--
作者：
Luo, Zhongli;Zhao, Xiaojun;Zhang, Shuguang
Self-assembling peptide nanofiber scaffolds are an excellent material for applications such as tissue repair, tissue regeneration, instant stopping of bleeding, and slow drug release. We report a new self-assembling peptide D-EAK16 consisting purely of D-amino acids. D-EAK16 and L-EAK16 display mirror-image CD spectra at 20 degrees C. Like L-EAK16, D-EAK16 self-assembles into nanofibers, thus demonstrating that chiral self-assembling peptide nanofiber scaffolds can be made from both Land D-amino acids. We also show that D-peptide nanofibers are resistant to natural proteases and may thus be useful in biotechnology, nanobiotechnology, tissue repair and tissue regeneration as well as other medical applications.
