Nutritional needs in environmental intoxication: vitamin E and air pollution, an example.
Nutritional needs in environmental intoxication: vitamin E and air pollution, an example.
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DOI：
10.1289/ehp.7929105
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发表时间：
1979-04
影响因子：
10.4
通讯作者：
中科院分区：
文献类型：
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膳食维生素E影响小鼠和大鼠对臭氧和二氧化氮的敏感性，表明自由基毒性机制。传统的过氧化不能完全解释肺脂肪酸组成的改变对二氧化氮和臭氧毒性的影响。本文提出了一个新的理论框架，即β，γ-烯丙基过氧自由基环化为单环和双环过氧化物，以解释食物与毒性的关系。类似的结果可能与其他毒物产生过氧化作用作为一种毒性机制。此类环状过氧化物可能模拟或干扰前列腺素系统。几种慢性疾病可能会通过这种微妙的毒性机制加剧。保护人体免受过氧化毒性所需的维生素E水平可能远高于目前美国的水平。S.饮食摄入
Dietary vitamin E affects the susceptibility of mice and rats to ozone and nitrogen dioxide, suggesting a free radical mechanism of toxicity. Conventional peroxidation does not completely explain the effects of alterations of lung fatty acid composition on both nitrogen dioxide and ozone toxicity. A new scheme is proposed based on the cyclization of beta, gamma-allylic peroxyl free radicals to monocyclic and bicyclic peroxides to explain the relationship between diet and toxicity. Similar results are likely with other toxicants producing peroxidation as a mechanism of toxicity. Such cyclic peroxides may mimic or interfere with the prostaglandin system. Several chronic diseases may be exacerbated through such a subtle toxic mechanism. The level of vitamin E needed for protection against peroxidation toxicity may be much greater than the present U. S. dietary intake.