Iridium-Catalyzed Asymmetric Hydrogenation of 2-Pyridyl Cyclic Imines: A Highly Enantioselective Approach to Nicotine Derivatives
Iridium-Catalyzed Asymmetric Hydrogenation of 2-Pyridyl Cyclic Imines: A Highly Enantioselective Approach to Nicotine Derivatives
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DOI：
10.1021/ja511422q
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发表时间：
2015-01-14
影响因子：
15
通讯作者：
Zhou, Qi-Lin
中科院分区：
文献类型：
--
作者：
Guo, Cui;Sun, Dong-Wei;Zhou, Qi-Lin
以铱为催化剂，手性螺膦恶唑啉为配体，建立了含吡啶环亚胺的高效不对称氢化反应。这一过程将促进新的尼古丁相关药物的开发。通过在吡啶环邻位引入取代基降低配位能力，保证了氢化反应的成功和优异的对映选择性。
A highly efficient asymmetric hydrogenation of cyclic imines containing a pyridyl moiety was established by using iridium catalysts with chiral spiro phosphine-oxazoline ligands. This process will facilitate the development of new nicotine-related pharmaceuticals. The introduction of a substituent at the ortho position of the pyridyl ring to reduce its coordinating ability ensures the success of the hydrogenation and excellent enantioselectivity.