Comparison of fetal growth in singleton, twin, and triplet pregnancies
Comparison of fetal growth in singleton, twin, and triplet pregnancies
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DOI：
10.1093/humrep/14.5.1352
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发表时间：
1999-05-01
影响因子：
6.1
通讯作者：
Hata, T
中科院分区：
文献类型：
--
作者：
Kuno, A;Akiyama, M;Hata, T
为探讨单胎小于胎龄儿(S胎龄儿)、单胎胎龄儿(S胎龄儿)、双胎胎龄儿(Tw胎龄儿)、三胞胎胎龄儿(Tri AGA)胎儿生长发育及胎儿器官发育的差异，对35例S胎龄儿、18例S胎龄儿、52例Tw胎龄儿及12例Tri胎龄儿进行了超声检查。于月经15周后每隔2周测量头部(HC)、腹部(AC)、脾(SC)、肾上腺(AGC)周长及股骨干长度(FDL)、肝脏长度(LL)、估计体重(EWT)。S-AGA、Tw-AGA和Tri-AGA的预测Hc值无显著差异，S-SGA的预测Hc值最低。随着月经年龄的增加，子宫内胎儿数增加，预测AC值的生长曲线斜率变小，但Tri-AGA和S-SGA的生长曲线斜率无显著差异。Tw-AGA、Tri-AGA和S-SGA胎儿的预测PDL值无显著差异，均显著低于S-AGA胎儿。Tw-AGA和Tri-AGA的预测EWT值无显著差异，介于S-AGA和S-SGA之间。S-AGA组和Tw-AGA组的预测SC和AGC值均无显著差异。而在S-SGA胎儿中，SC和AGC的生长曲线斜率低于另外两个月经年龄组。S-AGA、S-SGA和Tw-AGA的预测LL值略有差异，提示在AGA胎儿中，单胎、双胎和三胞胎之间的生长模式略有不同。
The objective of this longitudinal retrospective study was to evaluate differences of the fetal growth and fetal organ growth among singleton small for gestational age (S-SGA), singleton appropriate for gestational age (S-AGA), twin (Tw-AG), and triplet (Tri-AGA) infants, Ultrasonographic examinations were performed on 35 S-AGA, 18 S-SGA, 52 Tw-AGA and 12 Tri-AGA fetuses. Circumferences of head (HC), abdomen (AC), spleen (SC) and adrenal gland (AGC) and lengths of femur diaphysis (FDL), liver (LL), estimated weight (EWT) were measured every 2 weeks after 15 weeks of menstrual age until delivery. There was no significant difference in predicted HC values in S-AGA, Tw-AGA and Tri-AGA fetuses; these values were lowest in S-SGA fetuses. As the number of fetuses in the uterus increased with advancing menstrual age, the slope of the growth curve for predicted AC value became lower, but there was no significant difference between Tri-AGA and S-SGA fetuses. There was no significant difference in predicted PDL values among Tw-AGA,Tri-AGA and S-SGA fetuses; those values were significantly lower than that in S-AGA fetuses. There was no significant difference in predicted EWT value between Tw-AGA and Tri-AGA fetuses, which were intermediate between those for S-AGA and S-SGA fetuses. There were no significant differences in predicted SC and AGC values between S-AGA and Tw-AGA; fetuses, respectively. However, in S-SGA fetuses, the slopes of the growth curve for SC and AGC were lower than those in the other two groups with advancing menstrual age. There were slight differences in predicted LL values between S-AGA, S-SGA and Tw-AGA fetuses, These results suggest that in AGA fetuses, there was a slight difference in growth pattern among singleton, twin, and triplet pregnancies.