Conversion of propionate to liver glycogen in the intact rat, studied with isotopic propionate.
Conversion of propionate to liver glycogen in the intact rat, studied with isotopic propionate.
复制标题
用同位素丙酸盐研究了完整大鼠中丙酸盐向肝糖原的转化。
DOI：
10.1016/s0021-9258(19)51177-2
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发表时间：
1950
影响因子：
4.8
通讯作者：
J. Bordeaux
中科院分区：
文献类型：
--
作者：
V. Lorber;N. Lifson;W. Sakamt;H. Wood;M. Cook;J. Bordeaux
禁食大鼠将丙酸盐转化为肝糖原。在羧基碳原子处标记的丙酸盐产生在C3和C4处含有标记碳的葡萄糖（来自降解的糖原）。如果丙酸的α-或β-碳原子被标记，则所得肝糖原在葡萄糖分子中的位置1、2、5和6处含有标记的碳。鉴于用标记的乳酸盐获得的结果（参见前面的abst.），这种转化表明丙酮酸盐是丙酸盐转化为糖原的中间体。P. J.希尔德。
Propionate is converted by the fasting rat into liver glycogen. Propionate labelled at the carboxyl carbon atom gives rise to glucose (from degraded glycogen) containing labelled carbon at C 3 and C 4. If the α- or β-carbon atom of the propionate is labelled, the resulting liver glycogen contains the labelled carbon at positions 1, 2, 5 and 6 in the glucose molecule. In view of the results obtained with labelled laetate (see preceding abst.), such a conversion suggests that pyruvate is an intermediary in the conversion of propionate to glycogen.-P. J. Heald.