THE GLYCOCALYX AND TRAUMA: A REVIEW.
THE GLYCOCALYX AND TRAUMA: A REVIEW.
复制标题
糖脂和创伤：评论。
DOI：
10.1097/shk.0000000000000513
复制
发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Dull RO
中科院分区：
文献类型：
--
作者：
Chignalia AZ;Yetimakman F;Christiaans SC;Unal S;Bayrakci B;Wagener BM;Russell RT;Kerby JD;Pittet JF;Dull RO
在美国，创伤是45岁以下人群死亡的主要原因，每年夺去约192，000人的生命。严重的个人残疾、生产力损失和长期的医疗保健需求是常见的，每年造成5800亿美元的经济影响。改善创伤患者的复苏策略和早期急性护理有可能减少合并的过度炎症和免疫抑制的病理后遗症，这些后遗症可能共存或暂时发生，并对结果产生不利影响。内皮和上皮糖萼已成为炎症和免疫调节的重要参与者。糖萼的成分已被用作损伤严重程度的生物标志物，并有可能成为旨在免疫调节的治疗干预的靶标。在这篇综述中，我们提供了一个当代的了解的生理结构和功能的糖萼及其作用的创伤性损伤，特别是肺损伤。
In the United States trauma is the leading cause of mortality among those under the age of 45, claiming approximately 192,000 lives each year. Significant personal disability, lost productivity and long term healthcare needs are common and contribute 580 billion dollars in economic impact each year. Improving resuscitation strategies and the early acute care of trauma patients has the potential to reduce the pathological sequelae of combined exuberant inflammation and immune suppression that can co-exist, or occur temporally, and adversely affect outcomes. The endothelial and epithelial glycocalyx has emerged as an important participant in both inflammation and immunomodulation. Constituents of the glycocalyx have been used as biomarkers of injury severity and have the potential to be target(s) for therapeutic interventions aimed at immune modulation. In this review, we provide a contemporary understanding of the physiologic structure and function of the glycocalyx and its role in traumatic injury with a particular emphasis on lung injury.