The role of mesolimbic dopamine in conditioned locomotion produced by amphetamine.
The role of mesolimbic dopamine in conditioned locomotion produced by amphetamine.
复制标题
DOI：
10.1037//0735-7044.102.4.544
复制
发表时间：
1988-08
影响因子：
1.9
通讯作者：
L. Gold;N. Swerdlow;G. Koob
中科院分区：
文献类型：
--
作者：
L. Gold;N. Swerdlow;G. Koob
在独特的环境中每天服用精神运动兴奋剂可以赋予环境类似兴奋剂的特性。连续 5 天每天注射安非他明（0.75 mg/kg，皮下）的大鼠表现出强烈的非条件运动反应（在光电池笼中测量），并且在第 6 天用盐水处理时显示出条件运动反应。研究发现，当伏隔核损伤进行预处理或后处理时，这种条件性运动反应会因伏核的 6-羟基多巴胺 (6-OHDA) 损伤而显着减弱。同样，虽然伏隔核 6-OHDA 损伤的大鼠对阿朴吗啡（0.1 mg/kg，皮下）表现出强烈的超敏感非条件性运动亢进，但它们在测试当天并未表现出条件性反应。这些结果表明，中脑边缘多巴胺系统可能负责对精神运动兴奋药物的无条件和条件运动反应。此外，条件运动取决于突触前多巴胺的生理释放和突触后受体的占据之间的关键相互作用。
Daily administration of psychomotor stimulants in a distinctive environment can impart on the environment stimulantlike properties. Rats injected with amphetamine (0.75 mg/kg, sc) daily for 5 days exhibited a robust unconditioned locomotor response, measured in photocell cages, and showed a conditioned locomotor response when treated with saline on the 6th day. This conditioned locomotor response was found to be significantly attenuated by 6-hydroxydopamine (6-OHDA) lesions of the nucleus accumbens when the lesion was made either pre- or postconditioning. Similarly, although rats with 6-OHDA lesions of the nucleus accumbens exhibited a robust supersensitive unconditioned locomotor hyperactivity in response to apomorphine (0.1 mg/kg, sc), they did not show a conditioned response on the test day. These results suggest that the mesolimbic dopamine system may be responsible for both the unconditioned and conditioned locomotor responses to psychomotor stimulant drugs. Further, conditioned locomotion depends on a critical interaction between the physiological release of presynaptic dopamine and occupation of postsynaptic receptors.