REDUCED NATURAL-KILLER-CELL ACTIVITY IN PATIENTS WITH DEMENTIA OF THE ALZHEIMER TYPE
REDUCED NATURAL-KILLER-CELL ACTIVITY IN PATIENTS WITH DEMENTIA OF THE ALZHEIMER TYPE
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DOI：
10.1111/j.1600-0404.1991.tb04948.x
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发表时间：
1991-09-01
影响因子：
3.5
通讯作者：
TAKAHASHI, K
中科院分区：
文献类型：
--
作者：
ARAGA, S;KAGIMOTO, H;TAKAHASHI, K
我们检测了50例阿尔茨海默型痴呆患者（DAT）和37例年龄匹配的正常对照的自然杀伤（NK）细胞活性。DAT组NK细胞活性明显低于正常对照组。干扰素- α (ifn - α)或白细胞介素-2 （IL-2）诱导的NK细胞活性也明显低于正常对照组。两组患者血清IL-2、ifn - α水平差异无统计学意义。对于NK细胞亚群，双色流式细胞分析显示，两组中Leu-11+ Leu-7-细胞、Leu-11+ Leu-7+细胞和Leu-11- Leu-7+细胞的百分比差异无统计学意义。我们的研究结果表明，DAT中的NK细胞可能具有功能异常，并可能为DAT中基本的细胞和分子畸变提供重要线索。
We examined the natural killer (NK) cell activity in 50 patients with dementia of the Alzheimer type (DAT) and 37 age-matched normal controls. The NK cell activity in DAT was significantly lower than in the normal controls. The NK cell activity induced by either interferon-alpha (IFN-alpha) or interleukin-2 (IL-2) in DAT was also significantly lower than in the normal controls. There were no significant differences in the level of serum IL-2 and IFN-alpha between the two groups. As regards NK cell subsets, two-color flow cytometric analysis showed no significant differences between the percentages of Leu-11+ Leu-7- cells, Leu-11+ Leu-7+ cells and Leu-11- Leu-7+ cells in the two groups. Our results suggest that NK cells in DAT may have functional abnormalities and may provide important clues to fundamental cellular and molecular aberrations in DAT.