PARITY AS A RISK FACTOR FOR CERVICAL-CANCER
PARITY AS A RISK FACTOR FOR CERVICAL-CANCER
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DOI：
10.1093/oxfordjournals.aje.a115362
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发表时间：
1989-09-01
影响因子：
5
通讯作者：
RAWLS, WE
中科院分区：
文献类型：
--
作者：
BRINTON, LA;REEVES, WC;RAWLS, WE
在1986-1987年对哥伦比亚、哥斯达黎加、墨西哥和巴拿马的759名浸润性宫颈癌患者和1,430名对照进行的病例对照研究中，在调整了性和社会经济变量后，与怀孕次数的相关性仍然存在。对于那些怀孕14次或以上的人，风险稳步上升至5.1（95%置信区间2.7-9.7），在所有四个研究国家中观察到风险与多产的关系。妊娠关联似乎与活产的数量有关，而不是与流产或堕胎有关，多产关系在绝经前妇女和口服避孕药使用者中最为明显。人乳头状瘤病毒16型和18型，如通过原位杂交检测，与出生数没有显著相关性，也不能解释产次与风险的强烈关系。我们的研究结果表明，需要进一步考虑生殖因素对宫颈癌的风险，并注意可能的作用机制，包括激素因素和宫颈创伤。
In a case-control study of 759 invasive cervical cancer patients and 1,430 controls in Colombia, Costa Rica, Mexico, and Panama conducted during 1986-1987, an association with number of pregnancies persisted after adjustment for sexual and socioeconomic variables. Risks rose steadily to 5.1 (95% confidence interval 2.7-9.7) for those with 14 or more pregnancies and a relation of risk to multiparity was observed in all four study countries. Pregnancy associations appeared to relate to the number of live births rather than to miscarriages or abortions, with multiparity relations most pronounced among premenopausal women and oral contraceptive users. Human papillomaviruses types 16 and 18, as measured by filter in situ hybridization, were not significantly associated with number of births and did not explain the strong relation of parity to risk. Our results indicate the need for further consideration of reproductive factors on cervical cancer risk, with attention given to possible mechanisms of action, including hormonal factors and cervical trauma.