EFFECT OF SEROTONINERGIC DRUGS ON STRESS-INDUCED HYPERTHERMIA (SIH) IN MICE
EFFECT OF SEROTONINERGIC DRUGS ON STRESS-INDUCED HYPERTHERMIA (SIH) IN MICE
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DOI：
10.1007/bf01272765
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发表时间：
1990-01-01
期刊：
影响因子：
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通讯作者：
MELI, A
中科院分区：
文献类型：
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作者：
LECCI, A;BORSINI, F;MELI, A
8-OH-DPAT（2.5-10 mg/kg）和丁螺环酮（10 mg/kg），但不包括5，7-DHT（200 μ g/小鼠），pCPA（75和150 mg/kg，三次），利坦色林（0.1和0.2 mg/kg），LY 53857（1.5和3 mg/kg），GR 38032 F（0.1-100 μ g/小鼠），kg）、TFMPP（5和20 mg/kg）和mCPP（2.5和5 mg/kg）拮抗最后一批小鼠从其组舍中取出时发生的体温升高，这被称为应激诱导的体温过高（SIH）。Ro 15-1788在阻断地西泮对SIH作用的剂量下，未逆转丁螺环酮的抗焦虑作用。相反，当大脑5-HT含量减少到50%的5，7-二羟色胺诱导的损害，丁螺环酮对SIH的影响下降。TFMPP 5 mg/kg并没有显著缩短SIH的发作，这可能是一种焦虑药物所预期的，而20 mg/kg的剂量根本没有改变SIH的模式。低剂量的TFMPP诱发体温升高，而高剂量的TFMPP诱发体温降低。
8-OH-DPAT (2.5-10 mg/kg) and buspirone (10 mg/kg) but not 5,7-DHT (200 .mu.g/mouse), pCPA (75 and 150 mg/kg, three times), ritanserin (0.1 and 0.2 mg/kg), LY 53857 (1.5 and 3 mg/kg), GR 38032 F (0.1-100 .mu./kg), TFMPP (5 and 20 mg/kg) and mCPP (2.5 and 5 mg/kg) antagonized the rise in body temperature that occurs to the last mice removed from their group housing, which was termed as stress-induced hyperthermia (SIH). Ro 15-1788, at a dose which blocked the effect of diazepam on SIH, did not reverse the anxiolytic effect of buspirone. Instead, when cerebral 5-HT content was reduced to 50% by 5,7-DHT-induced lesion, the effect of buspirone on SIH was decreased. TFMPP 5 mg/kg did not shorten significantly the onset of SIH as could have been expected by an anxiogenic drug, while the dose of 20 mg/kg did not modify the pattern of SIH at all. The lower dose of TFMPP evoked a hyperthermic and the higher a hypothermic response.