Diuretic treatment of Meniere disease. Long-term results with chlorthalidone.
Diuretic treatment of Meniere disease. Long-term results with chlorthalidone.
复制标题
梅尼埃病的利尿治疗。
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
J. Stahle
中科院分区：
文献类型：
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作者：
I. Klockhoff;U. Lindblom;J. Stahle
用氯噻酮（Hygroton）治疗梅尼埃病34例，观察7年。26名患者表现出药物相关的改善，主要是眩晕的患病率和强度降低。在4名患者中，影响较小。四名患者似乎是完全耐氯噻酮，尽管积极的甘油试验，其中两人需要手术。220名严重残疾的病人也接受了氯噻酮治疗，他们住院接受进一步检查和最终手术。133例（60%）患者获得了改善，从而避免了手术。氯噻酮的定期或长期治疗在疾病活动期的许多患者中产生相当大的症状缓解。它减少了手术干预的需要，并帮助患者保持积极的生活，但不会阻止疾病的退行性过程。
Thirty-four patients with Meniere disease were treated with chlorthalidone (Hygroton) and observed for seven years. Twenty-six patients displayed drug-related improvements, primarily a reduction of the prevalence and intensity of vertigo. In four patients the effect was minor. Four patients appeared to be totally chlorthalidone-resistant, in spite of positive glycerin tests, and two of them needed operation. Chlorthalidone was also given to 220 severely incapacitated patients who were hospitalized for further examination and eventual operation. Improvements were obtained so that operation was avoided in 133 patients (60%). Periodic or long-term treatment with chlorthalidone produces a considerable symptomatic relief in many patients during the active stage of the disease. It reduces the need for surgical intervention and helps the patient retain an active life, but does not arrest the degenerative course of the disease.