Influence of indinavir on virulence and growth of Cryptococcus neoformans
Influence of indinavir on virulence and growth of Cryptococcus neoformans
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DOI：
10.1086/426828
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发表时间：
2005-01-15
影响因子：
6.4
通讯作者：
Vecchiarelli, A
中科院分区：
文献类型：
--
作者：
Monari, C;Pericolini, E;Vecchiarelli, A
茚地那韦可选择性抑制新生隐球菌某些毒力因子的产生，如尿素酶和蛋白酶，但不抑制黑色素和磷脂酶的产生;此外，茚地那韦还可干扰荚膜形成。这些作用导致C.新生儿对天然效应细胞的细胞内杀伤。与茚地那韦长时间孵育可抑制真菌生长。茚地那韦可以减弱真菌的毒力，从而增加其对天然效应细胞抗菌活性的敏感性。人类免疫缺陷病毒阳性患者隐球菌感染的减少也可能与高效抗逆转录病毒治疗的抗真菌活性有关。
Indinavir selectively inhibited production of some virulence factors of Cryptococcus neoformans, such as urease and protease, but not melanin and phospholipase; moreover, it interfered with capsule formation. These effects led to increased susceptibility of C. neoformans to intracellular killing by natural effector cells. Prolonged incubation with indinavir resulted in inhibition of fungal growth. Indinavir can attenuate the virulence of the fungus, thus augmenting its susceptibility to the antimicrobial activity of natural effector cells. The reduction in cryptococcal infections in human immunodeficiency virus-positive patients might also be related to the antifungal activity of highly active antiretroviral therapy.