An unusual melanocytic lesion associated with eccrine duct fibroadenomatosis and syringoid features.
An unusual melanocytic lesion associated with eccrine duct fibroadenomatosis and syringoid features.
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一种与小汗腺管纤维腺瘤病和注射管特征相关的不寻常的黑素细胞病变。
DOI：
10.1097/00000372-200104000-00010
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发表时间：
2001
影响因子：
1.1
通讯作者：
J. Bhawan
中科院分区：
文献类型：
--
作者：
C. Stefanato;D. Simkin;J. Bhawan
三岛强调了痣黑素细胞痣与外泌汗腺管的密切关系，这种痣黑素细胞痣与外泌汗腺管密切相关，这种痣黑素细胞痣的特征是痣黑素细胞主要在外泌汗腺管壁周围和内增殖。然而，在这些病变中，上覆的表皮、真皮或外分泌的肢端鞘管或真皮导管增殖没有变化。我们报告一位16岁的男孩，在右脚跟有一个直径0.6公分的褐色丘疹，临床上被认为是斯皮茨痣。组织学检查发现一个复合性痣黑素细胞痣与表皮增生，薄的真皮内延伸的肢端软脑膜上皮细胞索，和小汗腺导管增生的神经鞘瘤样模式与致密的纤维基质。我们的病例与外分泌中心痣的区别在于后者没有表皮和外分泌管增生和致密的纤维间质。在我们的病例中，足跟部的病变位置提示所观察到的病理变化可能是由重复性创伤引起的。
The intimate association of nevomelanocytic nevi with eccrine ducts commonly seen in congenital nevi was emphasized by Mishima, who described as eccrine-centered nevi those lesions characterized by nevomelanocytic cells predominantly proliferating around and within the eccrine sweat duct walls. However, there were no changes in the overlying epidermis, dermis, or eccrine acrosyringeal or dermal duct proliferation in these lesions. We present the case of a 16-year-old boy with a 1-year-history of a 0.6-cm diameter single tan papule on the right heel, clinically thought to be a Spitz nevus. Histopathologic examination revealed a compound nevomelanocytic nevus associated with epidermal hyperplasia, thin anastomosing cords of acrosyringeal epithelium extending within the dermis, and eccrine ductal proliferation in a syringoma-like pattern associated with a dense fibrous stroma. Features that distinguish our case from eccrine-centered nevus are that the latter lacks epidermal and eccrine duct hyperplasia and a dense fibrous stroma. The location of the lesion on the heel in our case suggests the possibility that the pathologic changes observed could result from repetitive trauma.