Lack of association between serum uric acid and organ damage in a never-treated essential hypertensive population at low prevalence of hyperuricemia
Lack of association between serum uric acid and organ damage in a never-treated essential hypertensive population at low prevalence of hyperuricemia
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DOI：
10.1016/j.amjhyper.2007.01.013
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发表时间：
2007-06-01
影响因子：
3.2
通讯作者：
Mancia, Giuseppe
中科院分区：
文献类型：
--
作者：
Cuspidi, Cesare;Valerio, Cristiana;Mancia, Giuseppe
背景资料：血尿酸（SUA）是否是高血压患者靶器官损害（TOD）和心血管事件的独立危险因素尚不明确。我们试图调查SUA与亚临床心脏，血管和肾脏的改变从未治疗的简单的原发性hypertensives.Methods：共580例患者最近诊断（< 1年）1级和2级高血压，分类的性别和三分位数的SUA水平，被认为是这项分析。所有受试者进行了广泛的临床，实验室和超声检查寻找心脏和心外TOD.Results：高尿酸血症（SUA > 7.0 mg/dL的男性和> 6 mg/dL的女性）是目前在8.3%的患者。左心室肥大（LVH）、颈动脉改变和微量白蛋白尿的总体患病率分别为28%、27%和8%。在整个人群的所有SUA三分位数中，以及在两种性别中，这些TOD标志物的患病率没有差异。SUA水平在有和无LVH、颈动脉病变或微量白蛋白尿的患者中相似。当患者根据受累器官的数量进行分类时，与单个或无器官受累的患者（4.9 +/-1.3或4.9 +/-1.4 mg/dL，P <0.05）相比，多个TOD（2或3个器官）患者的SUA水平显著更高（5.1 +/-1.3或5.2 +/-1.4 mg/dL）。然而，之间的关联，SUA水平和多个TOD.Conclusions的logistic回归analysis. We的研究结果不支持SUA作为一个独立的危险因素，亚临床TOD在选定的人口最近诊断为单纯高血压低患病率的高尿酸血症。
Background: It is still undefined whether serum uric acid (SUA) is an independent risk factor for target organ damage (TOD) and cardiovascular events in human hypertension. We sought to investigate the association of SUA with subclinical cardiac, vascular, and renal alterations in never-treated uncomplicated essential hypertensives.Methods: A total of 580 subjects with recently diagnosed (< 1 year) grade 1 and 2 hypertension, categorized by sex and tertiles of SUA levels, were considered for this analysis. All subjects underwent extensive clinical, laboratory, and ultrasonographic investigations searching for cardiac and extracardiac TOD.Results: Hyperuricemia (SUA > 7.0 mg/dL in men and > 6 mg/dL in women) was present in 8.3% of the patients. The overall prevalence of left-ventricular hypertrophy (LVH), carotid alterations, and microalbuminuria was 28%, 27%, and 8%, respectively. No differences in the prevalence rates of these TOD markers were present across all SUA tertiles in the entire population, as well as in both sexes. The SUA levels were similar in patients with and without LVH, carotid alterations, or microalbuminuria. When patients were classified according to the number of organs involved, those with multiple TOD (2 or 3 organs) had significantly higher SUA levels (5.1 +/- 1.3 or 5.2 +/- 1.4 mg/dL), as compared with those with a single or no organ involvement (4.9 +/- 1.3 or 4.9 +/- 1.4 mg/dL, P < .05). The association, however, between SUA levels and multiple TOD was not confirmed in a logistic regression analysis.Conclusions: Our findings do not support the role of SUA as an independent risk factor for subclinical TOD in a selected population of recently diagnosed uncomplicated hypertensives at low prevalence of hyperuricemia.