Adenoid cystic carcinoma of the tracheobronchial system: the role of postoperative radiotherapy.
Adenoid cystic carcinoma of the tracheobronchial system: the role of postoperative radiotherapy.
复制标题
气管支气管系统腺样囊性癌：术后放疗的作用。
作者：
T. Ogino;Ryousuke Ono;W. Shimizu;H. Ikeda
为了阐明气管支气管系统腺样囊性癌（ACC）术后放疗的作用，我们分析了在东京国立癌症中心医院接受治疗的患者。自1962年至1990年共收治ACC 7例，均行手术切除加术后放疗。没有一个原发性病变被完全手术切除。术后放疗采用标准分割，剂量范围为49.2-72戈伊。7例患者中有4例存活5年以上，最长21年，无局部复发。与此相反，另外3名在2年内复发的患者在5年前死于疾病。术后接受60戈伊或以上照射的4例患者中有3例获得局部控制。接受不到60戈伊的3例患者中有1例局部失败。手术切缘阳性的ACC患者术后高剂量放疗似乎可以改善局部控制并导致长期生存。
To clarify the role of postoperative radiotherapy for adenoid cystic carcinoma of the tracheobronchial system (ACC), we analyzed patients treated at the National Cancer Center Hospital, Tokyo. Seven patients with ACC were treated with resective surgery and postoperative radiotherapy from 1962-1990. None of the primary lesions was completely surgically resected. Postoperative irradiation was delivered by standard fractionation at a dose range of 49.2-72 Gy. Four of seven patients lived more than 5 years, up to 21 years, without local recurrence. In contrast, three other patients who showed recurrence within 2 years died of disease before 5 years. Three of four patients who received postoperative irradiation of 60 Gy or more attained local control. One of three patients who received less than 60 Gy failed locally. A high dose of postoperative radiotherapy for patients with a positive surgical margin of ACC seems to improve local control and result in long-term survival.