Choreography of recombination proteins during the DNA damage response.
Choreography of recombination proteins during the DNA damage response.
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DOI：
10.1016/j.dnarep.2009.04.007
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发表时间：
2009-09-02
期刊：
影响因子：
3.8
通讯作者：
Rothstein R
中科院分区：
文献类型：
--
作者：
Lisby M;Rothstein R
Genome integrity is frequently challenged by DNA lesions from both endogenous and exogenous sources. A single DNA double-strand break (DSB) is lethal if unrepaired and may lead to loss of heterozygosity, mutations, deletions, genomic rearrangements and chromosome loss if repaired improperly. Such genetic alterations are the main causes of cancer and other genetic diseases. Consequently, DNA double-strand break repair (DSBR) is an important process in all living organisms. DSBR is also the driving mechanism in most strategies of gene targeting, which has applications in both genetic and clinical research. Here we review the cell biological response to DSBs in mitotically growing cells with an emphasis on homologous recombination pathways in yeast Saccharomyces cerevisiae and in mammalian cells.
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影响因子：
56.9
作者：
Celeste, A;Petersen, S;Nussenzweig, A
通讯作者：
Nussenzweig, A
DOI：
10.1083/jcb.200510130
发表时间：
2006-04-24
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bekker-Jensen S;Lukas C;Kitagawa R;Melander F;Kastan MB;Bartek J;Lukas J
通讯作者：
Lukas J
影响因子：
16
作者：
Costanzo, V;Shechter, D;Gautier, J
通讯作者：
Gautier, J
影响因子：
4.8
作者：
Clerici, M;Mantiero, D;Longhese, MP
通讯作者：
Longhese, MP
影响因子：
4.8
作者：
Bhattacharyya, A;Ear, US;Bishop, DK
通讯作者：
Bishop, DK