Pattern of intrusions in verbal recall:: Comparison of Alzheimer's disease, Parkinson's disease, and frontal lobe dementia
Pattern of intrusions in verbal recall:: Comparison of Alzheimer's disease, Parkinson's disease, and frontal lobe dementia
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DOI：
10.1016/s0278-2626(01)80076-2
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发表时间：
2001-06-01
影响因子：
2.5
通讯作者：
Bédard, MA
中科院分区：
文献类型：
--
作者：
Rouleau, I;Imbault, H;Bédard, MA
尽管一些研究人员认为，在阿尔茨海默病患者中，单词列表学习的干扰更频繁，但最近的研究表明，这可能不是真的。事实上，侵入在许多神经退行性疾病中很常见。本研究的目的是检查由三组患者，即帕金森氏病（PD），阿尔茨海默氏病（AD），和痴呆症与突出的额叶符号学（FD）的患者的入侵的类型。虽然PD患者比其他两组学习了更多的单词（RAVLT试验1至5），但入侵总数没有显著差异。然而，两组之间观察到的非相关入侵的显着差异，PD患者的比例（15.48%）低于AD（45.5%）和FD（45.8%）患者的比例，这种类型的入侵。没有其他类型的入侵（同一类别，经常性，音素）显着区分三组之间。前摄干扰效应（PI），测量列表A和列表B回忆的第一次回忆之间的差异，PD比其他两组更强，反映了RAVLT上回忆的单词总数与PI效应的严重程度之间的强正相关。弗里尔列表入侵（从列表A的入侵，而回忆列表B项目）在FD比在其他两个组显着更明显。最后，几乎只在FD患者中观察到自由关联（一系列彼此相关但与目标项目无关的侵入）。三项发现说明了各种神经退行性疾病之间的一些质的差异。他们还强调AD和FD在言语学习方面的显著相似性。(C)中国科学出版社.
Although some researchers have suggested that intrusions in word list learning are more frequent in Alzheimer's disease, recent studies have shown that this might not be true. In fact, intrusions are common in many neurological degenerative diseases. The goal of the present study was to examine the types of intrusions made by three groups of patients, namely patients with Parkinson's disease (PD), Alzheimer's disease (AD), and dementia with prominent frontal lobe semiology (FD). Although PD patients learned more words (trials 1 to 5 on the RAVLT) than the two other groups, there was no significant difference in the total number of intrusions. However, significant differences between groups were observed for nonrelated intrusions, the proportion of PD patients (15.48) being lower than the proportion of AD (45.5%) and FD (45.8%) patients with this type of intrusions. No other type of intrusions (same category, recurring, phonemic) significantly differentiated between the three groups. The proactive interference effect (PI), measured as the difference between first recall of list A and list B recall, was stronger in PD than in the two other groups, reflecting the strong positive correlation between total number of words recalled on the RAVLT and severity of the PI effect. Frier list intrusions (intrusions from list A while recalling list B items) were significantly more pronounced in FD than in the two other groups. Finally, free associations (series of intrusions related to one another but not to the target items) were observed almost exclusively in FD patients. Three findings illustrate some qualitative differences between various neurological degenerative diseases. They also stress the marked similarities between AD and FD with regards to verbal learning. (C) zool Academic Press.