Phasic activation of monkey locus ceruleus neurons by simple decisions in a forced-choice task
Phasic activation of monkey locus ceruleus neurons by simple decisions in a forced-choice task
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DOI：
10.1523/jneurosci.2446-04.2004
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发表时间：
2004-11-03
影响因子：
5.3
通讯作者：
Aston-Jones, G
中科院分区：
文献类型：
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作者：
Clayton, EC;Rajkowski, J;Aston-Jones, G
去甲肾上腺素能蓝斑（LC）系统已被牵连在几个行为功能，最值得注意的是，响应显着的感觉事件。在这里，我们提供了新的证据表明，在执行简单的决定相关的反应的作用。我们研究了猴LC神经元在执行强迫选择辨别任务时的冲动活动。LC活动的时间比刺激呈现更紧密地跟踪行为反应。LC神经元被相位激活的行为反应之前，正确和不正确的标识，但没有激活的刺激，未能引起杠杆反应，也没有非任务相关的杠杆运动。我们假设，LC响应任务相关的决策过程的结果，促进他们的影响外显行为。LC在调节决策过程的行为结果中的作用与LC反应主要与感觉过程相关的更传统的观点形成对比。
The noradrenergic locus ceruleus (LC) system has been implicated in several behavioral functions, most notably, response to salient sensory events. Here, we provide new evidence indicating a role in the execution of responses associated with simple decisions. We examined impulse activity of monkey LC neurons during performance of a forced-choice discrimination task. The timing of LC activity more closely tracked behavioral responses than stimulus presentation. LC neurons were phasically activated preceding behavioral responses for both correct and incorrect identifications but were not activated by stimuli that failed to elicit lever responses nor by nontask-related lever movements. We hypothesize that the LC responds to the outcome of task-related decision processes, facilitating their influence on overt behavior. This role of the LC in regulating the behavioral outcome of decisional processes contrasts with more traditional views of LC responses as primarily related to sensory processes.