Mesenchymal Stem Cells in the Induction of Transplantation Tolerance

Mesenchymal Stem Cells in the Induction of Transplantation Tolerance
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DOI:
10.1097/tp.0b013e3181a287e6
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发表时间:
2009-05-15
期刊:
影响因子:
6.2
通讯作者:
Kenyon, Norma
Kenyon, Norma
中科院分区:
医学2区
文献类型:
--
作者:
Bartholomew, Amelia;Polchert, David;Kenyon, Norma

文献摘要

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Mesenchymal stem cells directly suppress ongoing immune responses. Through production of toleragenic cytokines, inhibition of lymphocyte proliferation, delivery of reparative and protective signals after reperfusion injury, and facilitation of hematopoietic chimerism, these cells demonstrate a wide-ranging potential for the development of multifaceted toleragenic strategies after transplantation.