SURVIVAL OF ORAL HUMAN IMMUNE SERUM GLOBULIN IN THE GASTROINTESTINAL-TRACT OF LOW-BIRTH-WEIGHT INFANTS
SURVIVAL OF ORAL HUMAN IMMUNE SERUM GLOBULIN IN THE GASTROINTESTINAL-TRACT OF LOW-BIRTH-WEIGHT INFANTS
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DOI：
10.1203/00006450-198109000-00006
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发表时间：
1981-01-01
影响因子：
3.6
通讯作者：
STIEHM, ER
中科院分区：
文献类型：
--
作者：
BLUM, PM;PHELPS, DL;STIEHM, ER
6名未成熟婴儿每天口服10%的不含维生素E的人免疫血清球蛋白1-8 ml/kg。第七个婴儿作为对照。未消化和部分消化的IgG检测粪便中的显着数量，但对照组婴儿。这种coproantibody保留了显着的调理活性的III型组B链球菌测定的化学发光法，但失去了大部分的破伤风抗体活性。新生儿的酶不成熟或快速通过时间允许完整的IgG或部分消化的IgG通过整个胃肠道。口服后新生儿粪便中完整IgG的存活可能表明特异性IgG抗体可以作为初乳伊加的替代品。口服IG在预防或治疗肠道感染（例如，大肠杆菌、霍乱弧菌、伤寒沙门氏菌、轮状病毒）或中毒（例如，婴儿肉毒杆菌中毒）。
Six immature infants were given oral feedings of 10% preservative-free human immune serum globulin ranging from 1-8 ml/kg per day. A 7th infant served as a control. Undigested and partially digested IgG was detected in the stools in significant quantities in all but the control infant. This coproantibody retained significant opsonic activity for type III group B streptococci as determined by a chemiluminescence assay, but lost most of its tetanus antibody activity. The newborn infants'' enzymatic immaturity or rapid transit time permits the passage of intact IgG or partially digested IgG to pass throughout the gastrointestinal tract. The survival of intact IgG in the stool of newborns after its oral administration may indicate that specific IgG antibody can serve as a colostral IgA substitute. Oral Ig may be of value in the prevention or treatment of enteric infections (e.g., Escherichia coli, Vibrio cholerae, Salmonella typhi, rotavirus) or intoxications (e.g., infantile botulism).