Functional roles of the cingulo-frontal network in performance on working memory
Functional roles of the cingulo-frontal network in performance on working memory
复制标题
DOI：
10.1016/j.neuroimage.2003.09.046
复制
发表时间：
2004-01-01
期刊：
影响因子：
5.7
通讯作者：
Shibasaki, H
中科院分区：
文献类型：
--
作者：
Kondo, H;Morishita, M;Shibasaki, H
我们考察了大脑活动与工作记忆上的任务表现之间的关系。最初进行了一项大规模研究，以确定使用操作广度和阅读广度任务的表现好和差的人。在这些广度得分的基础上，我们将20名同意的参与者分为高广度组和低广度组。在一项功能磁共振研究中，参与者同时或分开对算术问题和目标单词的记忆进行了验证。行为研究结果表明，在双任务条件下，高广度组的成绩好于低广度组，但在两个单任务条件下，高广度组的成绩不如低广度组。两个SPAN组的前扣带回皮质(ACC)、左前额叶皮质(PITC)、左下额叶皮质和双侧顶叶皮质均被激活。我们发现，在双任务条件下，高广度组比低广度组的ACC信号变化更大，而在单任务条件下，高广度组的信号变化不明显。结构方程模型显示，高广度组从ACC到左侧PFC的有效连接估计为正，而低广度组为负，这表明两个大脑区域之间的更紧密合作与工作记忆成绩密切相关。我们的结论是，中央执行功能的注意转移是由扣带额叶网络调制的。(C)2003 Elsevier Science Inc.保留所有权利。
We examined the relationship between brain activities and task performance on working memory. A large-scale study was initially administered to identify good and poor performers using the operation span and reading span tasks. On the basis of those span scores, we divided 20 consenting participants into high-and low-span groups. In an fMRI study, the participants performed verification of arithmetic problems and retention of target words either concurrently or separately. The behavioral results showed that performance was better in the high-span group than in the low-span group under a dual-task condition, but not under two single-task conditions. The anterior cingulate cortex (ACC), left prefrontal cortex (PITC), left inferior frontal cortex, and bilateral parietal cortex were primarily activated for both span groups. We found that signal changes in the ACC were greater in the high-span group than in the low-span group under the dual-task condition, but not under the single-task conditions. Structural equation modeling indicated that an estimate of effective connectivity from the ACC to the left PFC was positive for the high-span group and negative for the-low span group, suggesting that closer cooperation between the two brain regions was strongly related to working memory performance. We conclude that central executive functioning for attention shifting is modulated by the cingulo-frontal network. (C) 2003 Elsevier Science Inc. All rights reserved.