Paradoxical inhibition of solid tumor cell growth by bcl2.
Paradoxical inhibition of solid tumor cell growth by bcl2.
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DOI：
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发表时间：
1994-07
期刊：
影响因子：
11.2
通讯作者：
J. Pietenpol;N. Papadopoulos;S. Markowitz;J. Willson;K. Kinzler;B. Vogelstein
中科院分区：
文献类型：
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作者：
J. Pietenpol;N. Papadopoulos;S. Markowitz;J. Willson;K. Kinzler;B. Vogelstein
BCL 2基因产物已被证明可以防止细胞凋亡，并为许多细胞类型提供选择性生长优势。我们报告了bcl 2表达对几种实体瘤细胞系体外生长的意想不到的影响。bcl 2在这些细胞系中的表达导致与p53类似的生长抑制。相反，bcl 2的COOH-末端缺失突变体不能抑制生长。因此，bcl 2蛋白可能在不同的细胞类型中发挥不同的生物学作用。
The BCL2 gene product has been demonstrated to prevent apoptosis and provide a selective growth advantage to many cell types. We report an unexpected effect of bcl2 expression on the in vitro growth of several solid tumor cell lines. Expression of bcl2 in these cell lines resulted in growth inhibition similar to that seen with p53. In contrast, a COOH-terminal deletion mutant of bcl2 was unable to suppress growth. Thus, the bcl2 protein may exert distinct biological effects in different cell types.