Bone health of children with intestinal failure measured by dual energy X-ray absorptiometry and digital X-ray radiogrammetry
Bone health of children with intestinal failure measured by dual energy X-ray absorptiometry and digital X-ray radiogrammetry
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DOI：
10.1016/j.clnu.2017.02.014
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发表时间：
2018-04-01
影响因子：
6.3
通讯作者：
Hulst, Jessie
中科院分区：
文献类型：
--
作者：
Neelis, Esther;Rijnen, Noortje;Hulst, Jessie
背景和目标：肠衰竭（IF）儿童接受长期肠外营养（PN）有发生低骨密度（BMD）的风险。除了双能X射线吸收测量法（DXA），使用BoneXpert软件的数字X射线放射测量法（DXR）也可用于获得手部X光片中的骨健康指数（BHI）。在这项研究中，我们1）使用DXA和DXR评估IF儿童低BMD的患病率，2）比较DXA和DXR结果，3）旨在确定与低BMD相关的因素。方法：进行回顾性研究，包括2000年至2015年期间接受DXA测量和/或手部X光片的所有IF儿童。收集全身BMD（BMD TB）和腰椎BMD（BMD LS）的Z值、骨矿物质表观密度（BMAD）和骨健康指数（BHI）。低BMD和低BHI被定义为Z评分
Background & aims: Children with intestinal failure (IF) receiving long-term parenteral nutrition (PN) are at risk of developing low bone mineral density (BMD). Next to the dual energy X-ray absorptiometry (DXA) method, digital X-ray radiogrammetry (DXR) using the BoneXpert software has become available to obtain the Bone Health Index (BHI) in hand radiographs. In this study we 1) evaluated the prevalence of low BMD in children with IF using DXA and DXR, 2) compared DXA and DXR results, and 3) aimed to identify factors associated with low BMD.Methods: A retrospective study was performed including all children with IF between 2000 and 2015 who underwent a DXA measurement and/or a hand radiograph. Z-scores of BMD total body (BMD TB) and lumbar spine (BMD LS), bone mineral apparent density (BMAD) and bone health index (BHI) were collected. A low BMD and low BHI were defined as a Z-score