Effects of neurotoxic doses of methamphetamine on potassium and amphetamine evoked overflow of dopamine in the striatum of awake rats
Effects of neurotoxic doses of methamphetamine on potassium and amphetamine evoked overflow of dopamine in the striatum of awake rats
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DOI：
10.1016/s0304-3940(98)00374-7
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发表时间：
1998-06-05
影响因子：
2.5
通讯作者：
Dugan, MT
中科院分区：
文献类型：
--
作者：
Cass, WA;Manning, MW;Dugan, MT
神经毒性剂量的甲基苯丙胺的基础和诱发溢出的多巴胺在纹状体的影响进行了研究，在清醒的大鼠使用微透析。将雄性Fischer-344大鼠施用甲基苯丙胺（5 mg/kg s.c.）或生理盐水，每天4次，间隔2小时。1周后进行微透析实验。多巴胺，3，4-二羟基苯乙酸和高香草酸的基础水平降低，在纹状体的甲基苯丙胺治疗的动物。局部应用过量的钾（100 mM）和安非他明（100 μ M），并腹腔注射安非他明（1.5 mg/kg），导致细胞外多巴胺水平增加的纹状体的甲基苯丙胺和盐水治疗的大鼠。然而，甲基苯丙胺给药动物的增加显著较少。用甲基苯丙胺治疗的大鼠纹状体中多巴胺和代谢物的组织水平降低。这些结果表明，治疗与神经毒性剂量的甲基苯丙胺可能会导致功能的变化，多巴胺释放在纹状体的Fischer-344大鼠。(C)1998由Elsevier Science爱尔兰有限公司出版。保留所有权利。
The effects of neurotoxic doses of methamphetamine on basal and evoked overflow of dopamine in the striatum were examined in awake rats using microdialysis. Male Fischer-344 rats were administered methamphetamine (5 mg/kg s.c.) or saline four times in 1 day at 2-h intervals. Microdialysis experiments were carried out 1 week later. Basal levels of dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid were reduced in the striatum of the methamphetamine-treated animals. Local application of excess potassium (100 mM) and amphetamine (100 mu M), and intraperitoneal injection of amphetamine (1.5 mg/kg), led to increased levels of extracellular dopamine in the striatum of both methamphetamine- and saline-treated rats. However, the increase was significantly less in the methamphetamine-treated animals. Tissue levels of dopamine and metabolites were reduced in the striata of rats treated with methamphetamine. These results indicate that treatment with neurotoxic doses of methamphetamine can lead to functional changes in dopamine release in the striatum of Fischer-344 rats. (C) 1998 Published by Elsevier Science Ireland Ltd. Ail rights reserved.