Plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after one and six half-life repeated administrations to rats
Plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after one and six half-life repeated administrations to rats
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DOI：
10.1016/0306-3623(95)02008-x
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发表时间：
1996-03-01
期刊：
影响因子：
--
通讯作者：
Fialip, J
中科院分区：
文献类型：
--
作者：
Coudore, F;Besson, A;Fialip, J
The purposes of the present study were as follows:1. After an acute intraperitoneal (IP) administration of amitriptyline (AMI) to male Sprague-Dawley rats we found that: (i) its absorbtion rate is rapid; (ii) its elimination half life is muck shorter than in humans; and (iii) its levels largely exceeded those of its metabolites. The most important metabolites being 10-hydroxynortriptyline and nortriptyline in plasma and brain, respectively.2. After six (every half life) repeated IP administrations: (i) AMI kinetic parameters were unchanged; and (ii) amounts of metabolites were significantly increased and the levels of AMI were lowered both in plasma and brain.
