Unexpected drug effects on autonomic function during myocardial ischaemia.
Unexpected drug effects on autonomic function during myocardial ischaemia.
复制标题
心肌缺血期间药物对自主神经功能的意外影响。
DOI：
10.1093/cvr/27.6.906
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发表时间：
1993
影响因子：
10.8
通讯作者：
X. Du
中科院分区：
文献类型：
--
作者：
A. Dart;X. Du
Anthony M Dart和Xiao-Jun Du在这里提供了大量证据，证明交感神经系统在心肌T缺血期间被激活，儿茶酚胺的释放在决定缺血发作的过程中是重要的，特别是在恶性心律失常的发生方面。’”许多患者在缺血发作时就已经在服用药物了，还有一些患者在缺血发作过程中接受了处方药物治疗。在过去几年中，从实验研究中可以清楚地看到，在许多情况下，从正常生理条件下观察得出的药物特性描述不能考虑到在病理情况下使用所引起的变化。这篇综述强调了心血管和非心血管药物在缺血性心脏交感神经递质释放方面的一些差异。心肌缺血引起突触后改变（如肾上腺素受体和肾上腺素受体的改变，心肌对肾上腺素能刺激的反应改变），这也可能改变各种药物的效果或效力。然而，交感神经传递的这些方面不在本综述的范围之内。
Anthony M Dart and Xiao-Jun Du here is substantial evidence that the sympathetic nervous system is activated during myocardial T ischaemia and that catecholamine release is important in determining the course of the ischaemic episode, particularly with respect to the occurrence of malignant arrhythmias.'" Many patients are already taking medication at the time of an ischaemic episode, and others are prescribed pharmacotherapy in the course of such an event. During the last few years, it has become clear from experimental studies that in many cases descriptions of drug properties derived from observations made under normal physiological conditions fail to allow for changes resulting from use under pathological circumstances. This review highlights some of these differences for both cardiovascular and non-cardiovascular drugs in relation to sympathetic neurotransmitter release in the ischaemic heart. Myocardial ischaemia induces postsynaptic changes (for example on ci and p adreno~ eptors,~ with altered myocardial responses to adrenergic stimulation) which may also alter the effects or potencies of various drugs. However these aspects of sympathetic neurotransmission fall outside the scope of this review.