Preoperative lymph-vascular space invasion is associated with nodal metastases in women with early-stage cervical cancer
Preoperative lymph-vascular space invasion is associated with nodal metastases in women with early-stage cervical cancer
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DOI：
10.1016/j.ygyno.2007.04.010
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发表时间：
2007-07-01
影响因子：
4.7
通讯作者：
Ramirez, Pedro T.
中科院分区：
文献类型：
--
作者：
Milam, Michael R.;Frumovitz, Michael;Ramirez, Pedro T.
目标。目的：探讨早期宫颈癌根治性子宫切除术术前活检结果与淋巴结累及（LNI）风险的关系。81例患者纳入回顾性研究。术前活检特征评估为分期、分级、组织学亚型、淋巴血管间隙浸润（LVSI）和浸润深度（bbb40mm）。12例患者（14.8%）在根治性子宫切除术中发生LNI。分期、分级和组织学亚型与LNI无关。LVSI和浸润> 4mm深度均与LNI显著相关（分别为25.6% vs. 4.8%， P= 0.0 1和25.0% vs. 4.5%， P= 0.0 1）——> 4mm浸润的LVSf在根治性子宫切除术时发生LNI的可能性是前者的6.6倍（RR=6.6； 95%可信区间为2.1-21.9）。术前LVSI患者在根治性子宫切除术中发生LNI的风险较高，应告知其治疗的潜在影响。(c) 2007爱思唯尔公司版权所有。
Objective. To determine the association between findings on review of preoperative biopsy specimens and the risk of lymph node involvement (LNI) at radical hysterectomy in patients with early-stage cervical cancer.Methods. Eighty-one patients were included in this retrospective review. Preoperative biopsy features evaluated were stage, grade, histologic subtype, lymph-vascular space invasion (LVSI), and depth (>4 mm) of invasion.Results. Twelve patients (14.8%) had LNI at radical hysterectomy. Stage, grade, and histologic subtype were not associated with LNI. LVSI and depth of invasion >4 mm were both significantly associated with LNI (25.6% vs. 4.8%, P= 0.0 1, and 25.0% vs. 4.5%, P= 0.0 1, respectively)- LVSf with >4 mm invasion was 6.6 times more likely to have LNI at the time of radical hysterectomy (RR=6.6; 95% confidence interval, 2.1-21.9).Conclusion. Patients with preoperative LVSI are at higher risk for LNI at radical hysterectomy and should be counseled regarding potential implications for management. (c) 2007 Elsevier Inc. All rights reserved.