Individualizing the aorto-radial pressure transfer function: feasibility of a model-based approach
Individualizing the aorto-radial pressure transfer function: feasibility of a model-based approach
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DOI：
10.1152/ajpheart.2000.279.2.h542
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发表时间：
2000-08-01
影响因子：
4.8
通讯作者：
Verdonck, P
中科院分区：
文献类型：
--
作者：
Segers, P;Carlier, S;Verdonck, P
我们使用无创测量（张力测量）桡动脉和颈动脉压力 (P-car)，在 31 名对照者和 30 名冠状动脉疾病患者中安装了桡动脉-颈动脉/主动脉压力传递函数 (TFF) 的三段传输线模型。除了远端反射系数（患者为 0.85 +/- 0.21，对照为 0.71 +/- 0.25；P < 0.05）外，患者或对照之间的模型参数没有差异。参数与血压、年龄或心率无关。我们进一步评估了点对点平均 TFF (TFFavg) 以及上包络 TFF (TFFmax) 和下包络 TFF (TFFmin)。脉压 (PP) 和增强指数 (AIx) 是在原始和重建的 P-car (P-car,P-r) 上得出的。 TFFavg 在 P-car 和 P-car、P-r（均方根 = 4.3 +/- 2.3 mmHg）之间产生最接近的形态学一致性，TTFavg 最佳预测 PP（测量的 41.5 +/- 11.8 与 41.1 +/- 10.0 mmHg）和 AIx（20.02 +/- 0.19 与 0.01 +/- 0.19）。无论使用何种 TFF，根据 P-car 或 P-car,P-r 计算得出的 PP 和 AIx 在患者中均高于对照组。我们得出的结论是：1) 平均 TFF 在重建和测量的压力波形与随后导出的 AIx 之间产生显着差异； 2）不同的 TFF 似乎保留了压力波中区分对照组和患者的信息。
We fitted a three-segment transmission line model for the radial-carotid/aorta pressure transfer function (TFF) in 31 controls and 30 patients with coronary artery disease using noninvasively measured (tonometry) radial and carotid artery pressures (P-car). Except for the distal reflection coefficient (0.85 +/- 0.21 in patients vs. 0.71 +/- 0.25 in controls; P < 0.05), model parameters were not different between patients or controls. Parameters were not related to blood pressure, age, or heart rate. We further assessed a point-to-point averaged TFF (TFFavg) as well as upper (TFFmax) and lower (TFFmin) enveloping TFF. Pulse pressure (PP) and augmentation index (AIx) were derived on original and reconstructed P-car (P-car,P-r). TFFavg yielded closest morphological agreement between P-car and P-car,P-r (root mean square = 4.3 +/- 2.3 mmHg), and TTFavg best predicted PP (41.5 +/- 11.8 vs. 41.1 +/- 10.0 mmHg measured) and AIx (20.02 +/- 0.19 vs. 0.01 +/- 0.19). PP and AIx, calculated from P-car or P-car,P-r, were higher in patients than in controls, irrespectively of the TFF used. We conclude that 1) averaged TFF yield significant discrepancies between reconstructed and measured pressure waveforms and subsequent derived AIx; and 2) different TFFs seem to preserve the information in the pressure wave that discriminates between controls and patients.