The midbrain to pons ratio A simple and specific MRI sign of progressive supranuclear palsy
The midbrain to pons ratio A simple and specific MRI sign of progressive supranuclear palsy
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DOI：
10.1212/wnl.0b013e318292a2d2
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发表时间：
2013-05-14
期刊：
影响因子：
9.9
通讯作者：
Micallef, Caroline
中科院分区：
文献类型：
--
作者：
Massey, Luke A.;Jaeger, Hans R.;Micallef, Caroline
目的：用于诊断进行性核上性麻痹（PSP）的基于mri的测量通常缺乏病理验证，并且不容易常规使用。我们的目的是在组织学证实的疾病中发展一种在矢状面MRI上对中脑和脑桥的简单测量来识别PSP。方法：对确诊的PSP （n = 12）、帕金森病（n = 2）和多系统萎缩（MSA） （n = 7）以及对照组（n = 8）进行中脑和脑桥基底的正中矢状面t1加权MRI测量。采用受试者工作特征曲线分析，将截止值应用于临床诊断的62名受试者，包括PSP （n = 21）、帕金森病（n = 10）、MSA （n = 10）和对照组（n = 21）。结果：PSP的平均中脑测量值减少了8.1 mm (p < 0.001)，中脑与脑桥比值减少（PSP小于MSA， p < 0.001）。在对照组中，平均中脑比例约为脑桥基底的三分之二，在PSP中是这样
Objectives: MRI-based measurements used to diagnose progressive supranuclear palsy (PSP) typically lack pathologic verification and are not easy to use routinely. We aimed to develop in histologically proven disease a simple measure of the midbrain and pons on sagittal MRI to identify PSP.Methods: Measurements of the midbrain and pontine base on midsagittal T1-weighted MRI were performed in confirmed PSP (n = 12), Parkinson disease (n = 2), and multiple system atrophy (MSA) (n = 7), and in controls (n = 8). Using receiver operating characteristic curve analysis, cutoff values were applied to a clinically diagnosed cohort of 62 subjects that included PSP (n = 21), Parkinson disease (n = 10), MSA (n = 10), and controls (n = 21).Results: The mean midbrain measurement of 8.1 mm was reduced in PSP (p < 0.001) with reduction in the midbrain to pons ratio (PSP smaller than MSA; p < 0.001). In controls, the mean midbrain ratio was approximately two-thirds of the pontine base, in PSP it was