Idiotypic and genetic studies of human rheumatoid factors.
Idiotypic and genetic studies of human rheumatoid factors.
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人类类风湿因子的独特型和遗传学研究。
DOI：
10.1002/art.1780301201
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发表时间：
1987
影响因子：
--
通讯作者：
Fong,S
中科院分区：
文献类型：
--
作者：
Carson,DA;Chen,PP;Kipps,TJ;Radoux,V;Jirik,FR;Goldfien,RD;Fox,RI;Silverman,GJ;Fong,S
在70-80%的类风湿性关节炎患者的血清中发现了针对IgG的Fc片段的IgM自身抗体，并因此被称为类风湿因子（RF）。然而，患有干燥综合征和混合型冷球蛋白血症的患者，以及患有一些常见感染性疾病的患者，也可能具有丰富的血清IgM抗IgG自身抗体。IgM-RF的瞬时合成通常伴随人类和动物的二次免疫应答（1-3）。由于这些原因，将抗IgG自身抗体指定为类风湿因子主要具有历史意义。RF的大多数研究都集中在自身抗体在免疫复合物形成和由此产生的组织损伤中的致病作用。近年来，一些研究小组试图阐明控制RF合成和特异性的分子遗传因素。这些实验的目的是了解为什么抗IgG自身抗体
IgM autoantibodies against the Fc fragment of IgG are found in the sera of 70-80% of patients with rheumatoid arthritis, and have thus been termed rheumatoid factors (RF). However, patients with Sjogren’s syndrome and mixed cryoglobulinemia, as well as with a number of common infectious diseases, may also have abundant serum IgM anti-IgG autoantibodies. Transient synthesis of IgM-RF regularly accompanies secondary immune responses both in humans and animals (1-3). For these reasons, the designation of anti-IgG autoantibodies as rheumatoid factors is mainly of historical significance. Most investigations of RF have focused on the pathogenic role of the autoantibody in the formation of immune complexes and the resultant tissue damage. In recent years, several research groups have attempted to dlefine the molecular genetic factors that control RF synthesis and specificity. The goals of these experiments are to learn why anti-IgG autoantibodies are