Early growth, adult body size and prostate cancer risk
Early growth, adult body size and prostate cancer risk
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DOI：
10.1002/ijc.10810
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发表时间：
2003-01-10
影响因子：
6.4
通讯作者：
Hopper, JL
中科院分区：
文献类型：
--
作者：
Giles, GG;Severi, G;Hopper, JL
从出生到青春期和成年期间生长的作用一直是关于前列腺癌风险的流行病学调查的主题，但证据仍然薄弱且不一致。我们在 1994 年至 1998 年间在澳大利亚开展了一项基于人群的病例对照研究，调查了前列腺癌风险与身体生长、体型和体型变化等多项标志物之间的关联。我们分析了从 1,476 名病例和 1,409 名对照者的面对面访谈中获得的数据。感兴趣的主要结果是青春期生长突增的时间、痤疮的经历和采访者对面部痤疮疤痕的观察、21岁时的体型、参考年的体型、最大体重和自21岁以来体型的变化率。对所有病例以及肿瘤分级进行了分析。我们发现 21 岁或成年后的体重指数和去脂体重等身体尺寸指标没有关联。生长突增晚于朋友会降低风险（比值比 [OR] 0.79 [0.63-0.97]），并且某些痤疮测量指标的比值比也小于 1，例如，面部痤疮疤痕的 OR 为 0.67 (0.45-1.00)。我们得出的结论是，雄激素作用延迟的标志物，例如青春期生长突增延迟，以及青春期其他雄激素依赖性活动的标志物，例如面部痤疮疤痕，与前列腺癌风险相关，但我们无法检测到与成人体型和生长（包括去脂体重）标志物之间的关联。 (C) 2002 Wiley-Liss, Inc.
The role of growth from birth through puberty and through adult life has been the subject of epidemiologic investigation in regard to the risk of prostate cancer but the evidence remains weak and inconsistent. We investigated associations between prostate cancer risk and a number of markers of body growth, size and changes to size in a population-based, case-control study in Australia from 1994 to 1998. We analyzed data obtained in face-to-face interviews from 1,476 cases and 1,409 controls. The main outcomes of interest were the timing of the growth spurt in adolescence, the experience of acne and interviewer observation of facial acne scarring, body size at age 21, body size in reference year, maximum body weight and rate of body size change since age 21 years. Analysis was performed on all cases and also by tumour grade. We found no associations with measures of body size including body mass index and lean body mass at age 21 or later in adult life. Having a growth spurt later than friends reduced risk (odds ratio [OR] 0.79 [0.63-0.97]) and some measures of acne also gave odds ratios less than 1, for example, having facial acne scarring gave an OR of 0.67 (0.45-1.00). We conclude that markers of delayed androgen action, such as delayed growth spurt in puberty, and markers of other androgen-dependent activity in puberty, such as facial acne scarring, are associated with prostate cancer risk but we could detect no associations with markers of adult body size and growth including lean body mass. (C) 2002 Wiley-Liss, Inc.