Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects
Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects
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DOI：
10.1117/1.3425884
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发表时间：
2010-05-01
影响因子：
3.5
通讯作者：
Licht, Daniel J.
中科院分区：
文献类型：
--
作者：
Durduran, Turgut;Zhou, Chao;Licht, Daniel J.
我们对先天性心脏病新生儿 (n=33) 采用混合漫相关光谱 (DCS) 和近红外光谱 (NIRS) 监测仪。 NIRS-DCS 装置测量高碳酸血症期间氧合血红蛋白、脱氧血红蛋白和总血红蛋白浓度的变化；脑血流量（rCBF（DCS））；和氧代谢（rCMRO(2)）。与动脉自旋标记磁共振成像（rCBF（ASL-MRI），n = 12）同时进行的测量将rCBF（DCS）与rCBF（ASL-MRI）进行交叉验证，显示出良好的一致性（R = 0.7，p = 0.01）。该研究展示了 NIRS-DCS 在危重新生儿群体中的应用，结果表明光学技术是监测该群体的一种有前途的临床方法。 (C) 2010 年光电仪器工程师协会。 [DOI：10.1117/1.3425884]
We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBF(DCS)); and oxygen metabolism (rCMRO(2)). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF(ASL-MRI), n=12) cross-validate rCBF(DCS) against rCBF(ASL-MRI), showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3425884]