Assessment of cortisol response with low-dose and high-dose ACTH in patients with chronic fatigue syndrome and healthy comparison subjects
Assessment of cortisol response with low-dose and high-dose ACTH in patients with chronic fatigue syndrome and healthy comparison subjects
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DOI：
10.1176/appi.psy.44.2.113
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发表时间：
2003-03-01
期刊：
影响因子：
3.4
通讯作者：
Ehlert, U
中科院分区：
文献类型：
--
作者：
Gaab, J;Hüster, D;Ehlert, U
皮质醇分泌减少被认为是慢性疲劳综合征症状的一种可能解释。然而，慢性疲劳综合征中皮质醇减少的证据是相互矛盾的。为了同时评估肾上腺皮质敏感性和肾上腺分泌储备的可能改变，作者对一组18名慢性疲劳综合征患者和18名年龄和性别匹配的健康对照受试者给予低剂量和高剂量ACTH。无论是低剂量还是高剂量ACTH给药后，唾液和血浆皮质醇均无反应差异，表明原发性肾上腺皮质功能不全不太可能在慢性疲劳综合征的病因学中发挥重要作用。
A reduced secretion of cortisol has been proposed as a possible explanation of the symptoms in chronic fatigue syndrome. However, the evidence of hypocortisolism in chronic fatigue syndrome is conflicting. In order to simultaneously assess possible alterations in adrenocortical sensitivity and secretory adrenal reserve, the authors administered both low-dose and high-dose ACTH to a group of 18 chronic fatigue syndrome patients and 18 age- and gender-matched healthy comparison subjects. No response differences for salivary and plasma cortisol were detectable after administration of either low-dose or high-dose ACTH, indicating that primary adrenal insufficiency is unlikely to play a significant role in the etiology of chronic fatigue syndrome.