The contribution of transposable elements to the evolution of regulatory networks
The contribution of transposable elements to the evolution of regulatory networks
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发表时间：
2008
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通讯作者：
Cédric Feschotte
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作者：
Cédric Feschotte
真核生物基因表达的调控和协调依赖于转录和转录后调控网络。尽管在绘制这些网络的组成部分和破译这些网络的功能方面取得了进展，但人们对这种复杂回路的起源和演化机制仍然知之甚少。在这里，我重新审视并扩展了早期的模型，提出基因组重复序列，特别是转座元件，已经成为真核生物基因调控系统组装和修补的丰富材料来源。
The control and coordination of eukaryotic gene expression rely on transcriptional and posttranscriptional regulatory networks. Although progress has been made in mapping the components and deciphering the function of these networks, the mechanisms by which such intricate circuits originate and evolve remain poorly understood. Here I revisit and expand earlier models proposing that genomic repeats, and in particular transposable elements, have been a rich source of material for the assembly and tinkering of eukaryotic gene regulatory systems.