Antibodies to Viral and Mammalian Native DNA in Response to BK Virus Inoculation and Subsequent Immunization with Calf Thymus DNA
Antibodies to Viral and Mammalian Native DNA in Response to BK Virus Inoculation and Subsequent Immunization with Calf Thymus DNA
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BK 病毒接种和后续小牛胸腺 DNA 免疫反应中的病毒和哺乳动物天然 DNA 抗体
DOI：
10.1111/j.1365-3083.1991.tb01526.x
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发表时间：
1991
影响因子：
3.7
通讯作者：
O. Rekvig
中科院分区：
文献类型：
--
作者：
K. Fredriksen;B. Brannsether;T. Traavik;O. Rekvig
Recent studies have demonstrated that anti‐DNA antibodies share important genetical features with antibodies to exogenous antigens, suggesting that anti‐DNA antibody responses may be (auto‐) antigen driven. We have earlier defined three out of five rabbits as anti‐dsDNA antibody responders based on reactivity with calf thymus (CT) dsDNA after inoculation with the human dsDNA virus BK. In the present study we demonstrate that all five animals that received BK virus inoculations produced antibodies to BK virus dsDNA. These antibodies did not cross‐react with CT dsDNA, as shown by inhibition experiments. The anti‐BK dsDNA antibodies persisted over time, in contrast to the anti‐CT dsDNA antibodies that decreased shortly after a peak following the first boost of BK virus. While the anti‐CT dsDNA antibodies decreased, the anti‐BK dsDNA antibodies remained elevated, thus supporting the results of the inhibition experiments which showed that two independent antibody populations are produced after BK virus inoculations. In the three animals producing anti‐mammalian dsDNA antibodies, antibodies recognizing CT dsDNA reappeared after intravenous administration of a complex of CT dsDN A and methylated bovine serum albumin (MBSA) without adjuvant. The latter anti‐CT dsDNA antibodies did not cross‐react with BK dsDNA. In contrast to earlier studies we conclude that mammalian dsDNA may be immunogenic, and that discrete molecular differences in DNA antigens from different sources may induce anti‐dsDNA antibodies specific for dsDNA molecules of different origin.
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个体自身免疫小鼠体内的 IgG 抗 DNA 自身抗体是克隆选择的产物。
DOI：
--
发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Marion,TN;Bothwell,AL;Briles,DE;JanewayJr,CA
通讯作者：
JanewayJr,CA
通过细菌 DNA 免疫在正常小鼠中诱导抗双链 DNA 抗体。
DOI：
--
发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gilkeson,GS;Grudier,JP;Karounos,DG;Pisetsky,DS
通讯作者：
Pisetsky,DS
一个新的小鼠 Ig VH 基因家族。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kofler,R
通讯作者：
Kofler,R
DNA 的免疫化学。
影响因子：
5
作者：
Stollar,BD
通讯作者：
Stollar,BD