Axon deviation in the human lamina cribrosa
Axon deviation in the human lamina cribrosa
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DOI：
10.1136/bjo.82.6.680
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发表时间：
1998-06-01
影响因子：
4.1
通讯作者：
Foss, AJE
中科院分区：
文献类型：
--
作者：
Morgan, JE;Jeffery, G;Foss, AJE
目的：观察单个视网膜神经节细胞轴突穿过人眼筛板的过程。方法：用逆行示踪剂辣根过氧化物酶直接标记两只正常人眼的视神经，观察视网膜神经节细胞轴突穿过筛板的过程。结果：大多数轴突直接穿过筛板，但有相当一部分轴突偏离视盘中央和外周部分的筛板之间。结论：在青光眼等眼压升高的疾病中，这些轴突可能选择性地易受筛板的压迫。
Aims-To examine the course taken by individual retinal ganglion cell axons through the human lamina cribrosa.Methods-Retinal ganglion cell axons were labelled using the retrograde tracer horseradish peroxidase applied directly to the optic nerve in two normal human eyes removed during the course of treatment for extraocular disease.Results-A majority of axons took a direct course through the lamina cribrosa but a significant minority, in the range 8-12%, deviated to pass between the cribrosal plates in both central and peripheral parts of the optic disc.Conclusions-It is postulated that these axons would be selectively vulnerable to compression of the lamina cribrosa in diseases such as glaucoma in which the intraocular pressure is increased.