Analysis of the posterior cingulate cortex with [ 18 F]FDG-PET and Naa/mI in mild cognitive impairment and Alzheimer's disease: Correlations and differences between the two methods
Analysis of the posterior cingulate cortex with [ 18 F]FDG-PET and Naa/mI in mild cognitive impairment and Alzheimer's disease: Correlations and differences between the two methods
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DOI：
10.1590/1980-57642015dn94000385
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发表时间：
2015-12-01
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影响因子：
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通讯作者：
Buchpiguel, Carlos A.
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文献类型：
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作者：
Coutinho, Artur M.N.;Porto, Fábio H.G.;Buchpiguel, Carlos A.
通过[18 F]FDG-PET测量的后扣带回皮质（PCC）中局部脑葡萄糖代谢（rBGM）的降低与轻度认知障碍（MCI）向阿尔茨海默病（AD）的转化率较高相关。磁共振波谱（MRS）是一种潜在的生物标志物，已揭示MCI和AD中PCC内的Naa/mI降低。研究调查这两种models.Objective之间的关系是稀缺的：评估差异和可能的相关性rBGM和NAA/mI的结果在PCC的个人与AD，MCI和认知正常的志愿者.诊断为AD（N=32）或MCI（N=27）的患者和认知正常的老年人（CG，N=28）接受[18 F]FDG-PET和MRS分析PCC。比较了这两种方法，并调查了两种方法之间可能的相关性。结果：与CG相比，AD组在PCC中表现出rBGM降低，但在MCI组中则不然。MRS显示AD组NAA/mI值低于CG组，但MCI组无此现象。PCC中rBGM与NAA/mI呈正相关，PCC中NAA/mI降低区分AD患者和对照组的ROC曲线下面积为0.70，而[18 F]FDG-PET的ROC曲线下面积为0.93。结论：MCI和AD患者PCC中rBGM与Naa/mI呈正相关。[18 F]FDG-PET在区分AD患者和对照组方面比MRS具有更高的准确性。
Reduction of regional brain glucose metabolism (rBGM) measured by [18F]FDG-PET in the posterior cingulate cortex (PCC) has been associated with a higher conversion rate from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Magnetic Resonance Spectroscopy (MRS) is a potential biomarker that has disclosed Naa/mI reductions within the PCC in both MCI and AD. Studies investigating the relationships between the two modalities are scarce.OBJECTIVE: To evaluate differences and possible correlations between the findings of rBGM and NAA/mI in the PCC of individuals with AD, MCI and of cognitively normal volunteers.METHODS: Patients diagnosed with AD (N=32) or MCI (N=27) and cognitively normal older adults (CG, N=28), were submitted to [18F]FDG-PET and MRS to analyze the PCC. The two methods were compared and possible correlations between the modalities were investigated.RESULTS: The AD group exhibited rBGM reduction in the PCC when compared to the CG but not in the MCI group. MRS revealed lower NAA/mI values in the AD group compared to the CG but not in the MCI group. A positive correlation between rBGM and NAA/mI in the PCC was found. NAA/mI reduction in the PCC differentiated AD patients from control subjects with an area under the ROC curve of 0.70, while [18F]FDG-PET yielded a value of 0.93.CONCLUSION: rBGM and Naa/mI in the PCC were positively correlated in patients with MCI and AD. [18F]FDG-PET had greater accuracy than MRS for discriminating AD patients from controls.