Synthesis of Phenols: Organophotoredox/Nickel Dual Catalytic Hydroxylation of Aryl Halides with Water
Synthesis of Phenols: Organophotoredox/Nickel Dual Catalytic Hydroxylation of Aryl Halides with Water
复制标题
苯酚的合成：有机光氧化还原/镍双催化芳基卤化物与水的羟基化
DOI：
10.1002/anie.201710698
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Dong Xue
中科院分区：
文献类型：
--
作者：
Liu Yang;Zhiyan Huang;Gang Li;Wei Zhang;Rui Cao;Chao Wang;Jiangliang;Dong Xue
报道了在有机光氧化还原和镍协同催化下芳基卤与水的高效羟基化反应。酚类化合物的OH基来源于水，配体上的分子内碱基使其脱质子化。重要的是，芳基溴和反应活性较低的芳基氯可作为有效的底物来提供具有广泛官能团的苯酚，该方法不需要强的无机碱或昂贵的贵金属催化剂，可应用于各种苯酚的有效制备，并使多官能的药学相关芳基卤的羟基化成为可能。
Ahighly effective hydroxylation reaction of arylhalides with water under synergistic organophotoredoxandnickel catalysis is reported. The OH group of the resultingphenols originates from water,following deprotonation facili-tated by an intramolecular base group on the ligand. Signifi-cantly,aryl bromides as well as less reactive aryl chloridesserved as effective substrates to affordphenols with awiderange of functional groups.Without the need for astronginorganic base or an expensive noble-metal catalyst, thisprocess can be applied to the efficient preparation of diversephenols and enables the hydroxylation of multifunctionalpharmaceutically relevant aryl halides.