Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine
Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine
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DOI：
10.1016/s0960-894x(00)00689-2
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发表时间：
2001-02-26
影响因子：
2.7
通讯作者：
Durand, T
中科院分区：
文献类型：
--
作者：
Bezuglov, V;Bobrov, M;Durand, T
合成了C18、C20和C22系列不同脂肪酸与多巴胺的新酰胺。药理学特性的结合测定与大鼠脑膜制剂和大麻素的行为测试中的“四分体”表明，对于这些化合物，大麻素样活性依赖于脂肪酸部分。我们的数据表明，多烯脂肪酸酰胺与多巴胺组成了一个新的合成大麻拟似物家族。(C)2001年由Elsevier Science Ltd.出版
New amides of different fatty acids from the C18, C20, and C22 series with dopamine were synthesized. Pharmacological characterization in binding assays with rat brain membrane preparations and in the 'tetrad' of cannabinoid behavioral tests showed that, for these compounds, cannabinoid-like activity was dependent on the fatty acid moiety. Our data demonstrate that polyenoic fatty acid amides with dopamine comprise a new family of synthetic cannabimimetics. (C) 2001 Published by Elsevier Science Ltd.