Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair.
Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair.
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DOI：
10.1038/nrn3210
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发表时间：
2012-04-13
影响因子：
34.7
通讯作者：
Holt, Christine E.
中科院分区：
文献类型：
--
作者：
Jung, Hosung;Yoon, Byung C.;Holt, Christine E.
mrna可以靶向特定的神经元亚细胞结构域，从而通过局部翻译实现局部蛋白质组的快速变化。这种基于mrna的机制将外部信号与空间受限的细胞反应联系起来，并可以介导刺激驱动的适应性反应，如树突可塑性。局部mRNA翻译也发生在生长轴突，在那里它可以介导对引导信号的定向反应。最近的分析研究表明，生长和成熟的轴突都具有令人惊讶的复杂和动态的转录组，从而表明轴突mRNA定位受到高度调节，并在广泛的过程中发挥作用，这一观点越来越多地得到新的实验证据的支持。在这里，我们回顾了目前关于轴突mRNA翻译的作用和调节机制的知识，并讨论了轴突引导、生存、再生和神经系统疾病的新联系。
mRNAs can be targeted to specific neuronal subcellular domains, which enables rapid changes in the local proteome through local translation. This mRNA-based mechanism links extrinsic signals to spatially restricted cellular responses and can mediate stimulus-driven adaptive responses such as dendritic plasticity. Local mRNA translation also occurs in growing axons where it can mediate directional responses to guidance signals. Recent profiling studies have revealed that both growing and mature axons possess surprisingly complex and dynamic transcriptomes, thereby suggesting that axonal mRNA localization is highly regulated and has a role in a broad range of processes, a view that is increasingly being supported by new experimental evidence. Here, we review current knowledge on the roles and regulatory mechanisms of axonal mRNA translation and discuss emerging links to axon guidance, survival, regeneration and neurological disorders.
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影响因子：
4.5
作者：
Alexandrov, Ilya M.;Ivshina, Maria;Richter, Joel D.
通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.0703805104
发表时间：
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作者：
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作者：
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