The important role of the apoptotic effects of zinc in the development of cancers.
The important role of the apoptotic effects of zinc in the development of cancers.
复制标题
DOI：
10.1002/jcb.22049
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发表时间：
2009-04-01
影响因子：
4
通讯作者：
Costello, Leslie C.
中科院分区：
文献类型：
--
作者：
Franklin, Renty B.;Costello, Leslie C.
锌是细胞正常功能所必需的微量元素。它是多种细胞蛋白质（包括酶、转录因子和结构蛋白）的结构和功能的辅助因子。最近的研究表明，锌在多种癌症的发展中发挥着重要作用。不幸的是，尚未确定锌与癌症发生和进展的共同关系。已知锌具有全身效应，例如调节免疫系统以及直接细胞效应，从而调节基因表达、生物能量学、代谢途径、信号转导和细胞侵袭。据报道，锌还可以调节细胞增殖和生长。在这篇综述中，我们重点关注锌在恶性细胞凋亡调节中的作用。我们选择了锌的细胞凋亡作用，因为据报道锌既能诱导某些癌症的细胞凋亡，又能保护其他癌细胞免受其他因素诱导的细胞凋亡。锌在细胞凋亡调节中的作用似乎具有细胞类型特异性。更重要的是，必须从锌稳态生理调节的角度来看待锌对癌细胞的影响。因此，必须注意研究锌效应相对于原位存在的细胞锌分布和浓度的生理和病理条件的实验条件。
Zinc is a trace element that is essential for the normal function of cells. It is a cofactor for the structure and function of a wide range of cellular proteins including enzymes, transcription factors, and structural proteins. Recent studies have shown that zinc plays a role in the development of various cancers. Unfortunately no established common relationships of zinc with cancer development and progression have been identified. Zinc is known to have systemic effects such as regulation of the immune system as well as direct cellular effects resulting in regulation of gene expression, bioenergetics, metabolic pathways, signal transduction and cell invasion. Zinc is also reported to regulate cell proliferation and growth. In this review presentation we focus on the effects of zinc that are involved in the regulation of apoptosis in malignant cells. We selected the apoptotic effects of zinc because zinc is reported to both induce apoptosis in some cancers and to protect other cancer cells against apoptosis induced by other factors. The effects of zinc in the regulation of apoptosis appear to be cell type specific. More importantly the reported effects of zinc on cancer cells must be viewed from the perspective of the physiological regulation of zinc homeostasis. Thus one must be mindful of the experimental conditions under which zinc effects are investigated relative to the physiological and pathological conditions of cellular zinc distribution and concentrations that can exist in situ.
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BAX参与锌诱导的恶性前列腺细胞中的线粒体凋亡。
影响因子：
37.3
作者：
Feng, Pei;Li, Tieluo;Guan, Zhixin;Franklin, Renty B.;Costello, Leslie C.
通讯作者：
Costello, Leslie C.
影响因子：
37.3
作者：
Costello, Leslie C;Franklin, Renty B
通讯作者：
Franklin, Renty B
DOI：
10.1073/pnas.0709307104
发表时间：
2007-11-20
影响因子：
11.1
作者：
Li, Min;Zhang, Yuqing;Yao, Qizhi
通讯作者：
Yao, Qizhi
影响因子：
4.4
作者：
Chang, KL;Hung, TC;Cheng, HL
通讯作者：
Cheng, HL
影响因子：
4.8
作者：
Jiang, DM;Sullivan, PG;Weiss, JH
通讯作者：
Weiss, JH