Analysis of bolus formation in micropipette ejection systems
Analysis of bolus formation in micropipette ejection systems
复制标题
微量移液器喷射系统中团块形成的分析
DOI：
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Diwen Meng
中科院分区：
文献类型：
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作者：
P. Mirbod;Diwen Meng
在生物医学研究和临床研究中，药物从微吸管中被频繁地喷射出来，然而，对这个过程的动力学知之甚少。分散流体通过毛细管注入环境不混相流体的基本原理已被广泛研究。在这里，我们实验研究了微吸管喷射系统中的团粒形成，其中注射和环境流体是相同的。我们在实验上测量了同一流体中团状物质形成的时间演变。有三种不同的药丸形成机制来自不同的RET制度：a)近球形的药丸，b)梨形药丸，以及c)大变形或轴向喷流。我们考察了药丸的标度尺寸Rb/dt、lb/dt、H/dt和α，作为诸如尖端雷诺数、Ret、g/(Dt)的无量纲值等无量纲参数的函数。VT)、无因次时间TVT/DT和微吸管边缘与自由表面之间的距离D/DT。在整个时间范围内，0.2<；Ret<；30的团块半径根据t1/2增长，这使得我们能够估计完整团块形成的时间。
The ejection of drugs from micropipettes is practiced frequently in biomedical research and clinical studies however, little is known about the dynamics of this process. The fundamentals of disperse fluid injection via a capillary into an ambient immiscible fluid have been investigated extensively. Here, we experimentally investigate the bolus formation in micropipette ejection systems, where the injection and ambient fluid are the same. We experimentally measure the temporal evolution of the bolus formation in the same fluid. There are three different bolus formation mechanisms that arise from different Ret regimes: a) a nearly spherical bolus, b) a pear-like bolus, and c) a large distortion or axial jet. We examine the scaled dimensions of the bolus, Rb/Dt, Lb/Dt, H/Dt, and α, as a function of the dimensionless parameters such as tip Reynolds number, Ret, dimensionless value of g/(Dt. Vt), the dimensionless time, tVt/Dt, and the distance between the edge of the micropipette and the free surface, D/Dt. The bolus radius for 0.2 < Ret < 30 grows according to t1/2 in the entire time range, which allows us to estimate the time for complete bolus formation.Graphical abstract
使用斯托克斯流体刺激探针传递可量化的局部皮牛顿级力，研究骨细胞的电生理反应。
影响因子：
2.4
作者：
Wu,Danielle;Ganatos,Peter;Spray,DavidC;Weinbaum,Sheldon
通讯作者：
Weinbaum,Sheldon