COMPUTATIONAL CONSTRAINTS SUGGEST THE NEED FOR 2 DISTINCT INPUT SYSTEMS TO THE HIPPOCAMPAL CA3-NETWORK
COMPUTATIONAL CONSTRAINTS SUGGEST THE NEED FOR 2 DISTINCT INPUT SYSTEMS TO THE HIPPOCAMPAL CA3-NETWORK
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DOI：
10.1002/hipo.450020209
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发表时间：
1992-04-01
期刊：
影响因子：
3.5
通讯作者：
ROLLS, ET
中科院分区：
文献类型：
--
作者：
TREVES, A;ROLLS, ET
海马区的CA3网络可以作为自联结器运行，在其中，已知依赖于海马处理的陈述性记忆可以被存储，并随后利用CA3复发性侧支系统中可修改的突触效率被检索。在这一假设的基础上，作者探讨了外源性传入与CA3网络的计算相关性。对这种传入连接可能传递的信息进行的定量统计分析表明，需要两种不同的输入突触系统。第一个系统的突触需要是强大的(但不能关联地改变)，以便在学习期间迫使CA3细胞进入一种相对独立于从回返侧支接收的任何输入的活动模式，从而反映相当大数量的新信息。提出了苔藓纤维系统实现这一功能。需要第二个系统，在每个接收细胞上有大量可关联修改的突触，以便传递足够具体的信号来启动检索过程。我们认为，这可以通过CA3的穿孔路径输入来识别。
The CA3 network in the hippocampus may operate as an autoassociator, in which declarative memories, known to be dependent on hippocampal processing, could be stored, and subsequently retrieved, using modifiable synaptic efficacies in the CA3 recurrent collateral system. On the basis of this hypothesis, the authors explore the computational relevance of the extrinsic afferents to the CA3 network. A quantitative statistical analysis of the information that may be relayed by such afferent connections reveals the need for two distinct systems of input synapses. The synapses of the first system need to be strong (but not associatively modifiable) in order to force, during learning, the CA3 cells into a pattern of activity relatively independent of any inputs being received from the recurrent collaterals, and which thus reflects sizable amounts of new information. It is proposed that the mossy fiber system performs this function. A second system, with a large number of associatively modifiable synapses on each receiving cell, is needed in order to relay a signal specific enough to initiate the retrieval process. This may be identified, we propose, with the perforant path input to CA3.