Associations of salivary cortisol with cognitive function in the Baltimore memory study
Associations of salivary cortisol with cognitive function in the Baltimore memory study
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DOI：
10.1001/archpsyc.64.7.810
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发表时间：
2007-07-01
影响因子：
--
通讯作者：
Schwartz, Brian S.
中科院分区：
文献类型：
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作者：
Lee, Brian K.;Glass, Thomas A.;Schwartz, Brian S.
背景：下丘脑-垂体-肾上腺轴的应激反应会对大脑产生不利影响。以前的研究已经得出结论，皮质醇水平升高是认知功能障碍和衰老的风险因素，但受到性别排斥、认知电池限制和小样本量的限制。目的：检查城市成年人唾液皮质醇指标和认知领域得分之间的关系。设计、环境和参与者：一项横断面分析使用了一项纵向研究的数据，该研究涉及1140名年龄在50到70岁的马里兰州巴尔的摩居民。在一次研究访问中(在认知测试之前、期间、之后以及访问结束时)，从967名参与者那里获得了4个唾液皮质醇样本，从这些样本中创建了7个皮质醇指标。主要结果：对20项标准认知测试的成绩进行测量并合并，形成7个领域(语言、处理速度、眼手协调、执行功能、言语记忆和学习、视觉记忆和视觉建构)的总结性测量。结果：在研究访问期间，皮质醇水平较高、平均皮质醇水平以及皮质醇曲线下面积与较差的表现相关(P
Context: The stress responses of the hypothalamic-pituitary-adrenal axis can produce adverse effects on the brain. Previous studies have concluded that an elevated level of cortisol is a risk factor for cognitive dysfunction and decline in aging but have been limited by sex exclusion, restricted cognitive batteries, and small sample sizes.Objective: To examine associations among salivary cortisol metrics and cognitive domain scores in an urban adult population.Design, Setting, and Participants: A cross-sectional analysis was conducted using data from a longitudinal study involving 1140 Baltimore, Maryland, residents aged 50 to 70 years. Four salivary cortisol samples were obtained from 967 participants across 1 study visit (before, during, and after cognitive testing as well as at the end of the visit) from which 7 cortisol metrics were created. We examined associations of cortisol metrics with cognitive performance using multiple linear regression.Main Outcome Measures: Performance on 20 standard cognitive tests was measured and combined to form summary measures in 7 domains (language, processing speed, eye-hand coordination, executive functioning, verbal memory and learning, visual memory, and visuoconstruction).Results: Higher levels of pretest and mean cortisol as well as the area under the curve of cortisol over the study visit were associated with worse performance (P