PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness
PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness
复制标题
DOI：
10.1371/journal.pone.0067251
复制
发表时间：
2013-06-27
期刊：
影响因子：
3.7
通讯作者：
Beste, Christian
中科院分区：
文献类型：
--
作者：
Arning, Larissa;Ocklenburg, Sebastian;Beste, Christian
虽然人类的左右大脑半球在功能和解剖学上都不同，但这些半球专门化的基础机制以及它们的生理和行为影响仍然很大程度上未知。由于大脑的不对称性与利手密切相关，利手被认为是由一些遗传和环境因素的影响，我们进行了关联研究LRRTM1 rs6733871和PCSK 6的多态性和不同方面的利手评估与爱丁堡利手量表的样本无关的健康成人（n = 1113）。PCSK6（rs10523972）中的内含子33 bp可变数目串联重复（VNTR）多态性显示与利手类别比较（P = 0.0005）和利手程度（P = 0.001）显著相关（显著性阈值：p <0.0025，经多重比较调整）。这些结果提供了进一步的证据，PCSK 6作为候选人参与的生物学机制，建立正常的大脑侧化，从而利手和支持的假设，利手的程度，而不是方向，可能是更合适的指标大脑组织。
Although the left and right human cerebral hemispheres differ both functionally and anatomically, the mechanisms that underlie the establishment of these hemispheric specializations, as well as their physiological and behavioral implications, remain largely unknown. Since cerebral asymmetry is strongly correlated with handedness, and handedness is assumed to be influenced by a number of genetic and environmental factors, we performed an association study of LRRTM1 rs6733871 and a number of polymorphisms in PCSK6 and different aspects of handedness assessed with the Edinburgh handedness inventory in a sample of unrelated healthy adults (n = 1113). An intronic 33bp variable-number tandem repeat (VNTR) polymorphism in PCSK6 (rs10523972) shows a significant association (significance threshold: p < 0.0025, adjusted for multiple comparisons) with a handedness category comparison (P = 0.0005) and degree of handedness (P = 0.001). These results provide further evidence for the role of PCSK6 as candidate for involvement in the biological mechanisms that underlie the establishment of normal brain lateralization and thus handedness and support the assumption that the degree of handedness, instead the direction, may be the more appropriate indicator of cerebral organization.